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自身免疫性肝炎的研究进展
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Abstract:
自身免疫性肝炎是一种病因不明的慢性进展性肝脏疾病，随着人们对该病的认识及诊疗水平的提高，其发病率呈上升趋势。自身免疫性肝炎以免疫球蛋白水平升高、自身免疫性抗体阳性、肝组织学界面性炎为主要特征，治疗上可选择一线治疗、替代治疗和肝脏移植等治疗方案，但都有一定局限性。本文就自身免疫性肝炎的流行特点、发病机制、诊断、治疗及预后相关研究进展做一综述。
Autoimmune hepatitis is a chronic progressive liver disease of unknown etiology. With the im-provement of people’s understanding of the disease and the level of diagnosis and treatment, its in-cidence is on the rise. Autoimmune hepatitis is characterized by elevated immunoglobulin levels, positive autoimmune antibodies, and hepatic histological interface inflammation, and treatment options such as first-line therapy, replacement therapy, and liver transplantation are available, but all have limitations. This article reviews the research progress related to the epidemiological char-acteristics, pathogenesis, diagnosis, treatment and prognosis of autoimmune hepatitis.
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