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基质金属蛋白酶-9及其抑制剂在中枢神经系统免疫性疾病中的研究进展
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Abstract:
中枢神经系统免疫性疾病泛指一类由免疫机制介导的神经系统疾病，其发病机制十分复杂，血脑屏障(blood-brain barrier, BBB)的破坏在其中起着重要的作用。基质金属蛋白酶(matrix metallopro-teinases, MMPs)家族可通过降解基底膜及紧密连接等成分而破坏BBB，近年来研究发现MMP-9及抑制剂组织金属蛋白酶抑制因子-1 (Tissue inhibitor of metalloproteinase-1, TIMP-1)可通过破坏BBB而参与多种中枢神经系统免疫性疾病的疾病进程，并与疾病的严重程度与预后等相关。本文就MMP-9及TIMP-1在几种中枢神经系统免疫性疾病的研究进展做一综述。
Central nervous system immune diseases generally refer to kinds of nervous system diseases me-diated by immune mechanism. Their pathogenesis is very complex, and the destruction of blood- brain barrier (BBB) plays an important role in it. The matrix metalloproteinases (MMPs) family can destroy BBB by degrading basement membrane and tight junctions and other components. In re-cent years, it has been found that MMP-9 and its inhibitor tissue metalloproteinase inhibitor-1 (TIMP-1) take participate in disease process of various central nervous system immune diseases by destroying BBB. MMP-9 and TIMP-1 are related to the severity and prognosis of the disease. This article reviews research progress of MMP-9 and TIMP-1 in several central nervous system immune diseases.
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