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脑肠轴作为中枢神经系统疾病治疗靶点的研究进展
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Abstract:
脑肠轴是由胃肠道与中枢神经系统之间双向的信息交流组成，在大脑情绪和认知中枢与外周肠道功能相互沟通、相互影响中发挥着重要作用。在脑肠轴中，肠道微生物具有媒介作用，肠道微生物群可以通过调节营养物质代谢和合成分泌神经递质等途径来影响大脑的发育和功能。同时脑肠轴也参与多种中枢神经系统疾病的发生发展，如创伤性脑损伤、脑血管疾病、胶质瘤、阿尔茨海默病、抑郁症等疾病。本文将对脑肠轴作为中枢神经系统疾病治疗靶点进行综述如下。
The brain-gut axis is composed of two-way information exchange between the gastrointestinal tract and the central nervous system, and plays an important role in the communication and mutual influence between the emotional and cognitive center of the brain and the peripheral intestinal function. In the brain-gut axis, gut microbes play a mediating role, and gut microbiota can affect brain development and function by regulating nutrient metabolism and synthesizing and secreting neurotransmitters. At the same time, the brain-gut axis is also involved in the occurrence and development of various central nervous system diseases, such as traumatic brain injury, cer-ebrovascular disease, glioma, Alzheimer’s disease, depression and other diseases. In this paper, the brain-gut axis as a therapeutic target for central nervous system diseases is reviewed as follows.
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