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血清铁蛋白在成人急性髓系白血病治疗中的研究进展
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Abstract:
血清铁蛋白是一种去铁蛋白和铁核心形成的复合物，除作为储存铁外，血清铁蛋白还被作为一种癌症标志，血清铁蛋白通过铁依赖或非铁依赖的方式参与多种生物学过程，较高水平的血清铁蛋白能够促进急性髓系白血病的发生、发展和化疗耐药等过程。并且高血清铁蛋白在AML患者中是独立以及常见的导致不良预后的因素。因此，关于血清铁蛋白导致AML不良预后的研究，有希望为高血清铁蛋白的AML患者的治疗提供更为有针对性的选择方案。本文就血清铁蛋白在AML治疗中的研究进展作一综述。
Serum ferritin is a complex formed by ferritin and iron core. In addition to storing iron, serum ferri-tin is also used as a cancer marker. Serum ferritin participates in a variety of biological processes in an iron-dependent or non-iron-dependent manner. Higher levels of serum ferritin can promote the occurrence, development and chemoresistance of acute myeloid leukemia. And high serum ferritin is an independent and common factor leading to poor prognosis in AML patients. Therefore, the study on the adverse prognosis of AML caused by serum ferritin is hopeful to provide more targeted options for the treatment of AML patients with high serum ferritin. This article reviews the research progress of serum ferritin in the treatment of AML.
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