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肥胖合并糖尿病中脂肪组织巨噬细胞极化相关信号通路研究进展
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Abstract:
脂肪组织中过多的脂质积聚，既是肥胖的根源，也可能是慢性局部炎症的起因和结果，最近的研究表明，巨噬细胞可诱导许多其他特异性免疫疾病，因此在脂肪组织巨噬细胞活化过程中，巨噬细胞的招募、极化都是潜在的干预靶点。本文对脂肪组织慢性低级别炎症的发病机制及相关信号转导通路，包括AMPK通路，JNK信号通路，以及Notch信号通路进行了综述。为将来对慢性疾病如胰岛素抵抗、2型糖尿病的治疗干预提供一些思路和新的治疗方法。
Excessive lipid accumulation in adipose tissue is both a root cause of obesity and consequence of chronic local inflammation. Recent studies have shown that macrophages can induce specific im-mune characteristics. The process of macrophage activation in adipose tissue all are the potential targets for intervention, such as macrophages recruitment and polarization. This paper reviewed the pathogenesis of chronic low-grade inflammation in adipose tissue and related signal transduc-tion pathways, including AMPK pathway, JNK signaling pathway and Notch signaling pathway. It provides some ideas and new therapeutic methods for the treatment of chronic diseases such as insulin resistance and type 2 diabetes in the future.
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