|
|
青春期与成年期PCOS患者代谢的相关研究
|
Abstract:
多囊卵巢综合征(Polycystic ovary syndrome, PCOS)通常发生在青春期，以胰岛素抵抗、高胰岛素血症和高雄激素血症为特征。由于青少年的发育问题，青春期多囊卵巢综合症的诊断尤其困难。PCOS的很多症状，包括痤疮、月经不调和高胰岛素血症，在正常青春期中很常见。患有PCOS的青少年在以后的生活中出现如糖尿病、心血管疾病和不孕症等健康问题的风险比正常青少年大。了解多囊卵巢综合症青春期与成年期代谢特征的相关性有助于推动适时的管理，本综述的目的是了解青春期与成年期PCOS女性一般测量指标，女性激素特征及生化特征等方面了解其代谢相关性。
Polycystic ovary syndrome (PCOS) usually occurs during puberty and is characterized by insulin re-sistance, hyperinsulinemia, and hyperandrogenemia. Diagnosis of adolescent polycystic ovary syn-drome is particularly difficult due to developmental problems in adolescents. Many of the symp-toms of PCOS, including acne, menstrual irregularities and hyperinsulinemia, are common during normal adolescence. Adolescents with PCOS are at greater risk than non-PCOS adolescents of de-veloping health problems such as diabetes, cardiovascular disease and infertility later in life. Un-derstanding the correlation between adolescent and adult metabolic characteristics of polycystic ovary syndrome is helpful to promote timely management. The purpose of this review is to under-stand the general indicators of adolescent and adult PCOS in females, and understand their meta-bolic correlation from aspects such as female hormonal characteristics and biochemical character-istics.
| [1] | Hashemipour, M., Faghihimani, S., Zolfaghary, B., et al. (2004) Prevalence of Polycystic Ovary Syndrome in Girls Aged 14 - 18 Years in Isfahan, Iran. Hormone Research, 62, 278-282. https://doi.org/10.1159/000081842 |
| [2] | Singh, A., Vijaya, K. and Laxmi, K.S. (2018) Prevalence of Polycystic Ovary Syndrome among Adolescent Girls: A Prospective Study. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 7, 4375-4378.
https://doi.org/10.18203/2320-1770.ijrcog20184230 |
| [3] | Azziz, R., Woods, K.S., Reyna, R., et al. (2004) The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population. The Journal of Clinical Endo-crinology & Metabolism, 89, 2745-2749.
https://doi.org/10.1210/jc.2003-032046 |
| [4] | March, W.A., Moore, V.M., Willson, K.J., et al. (2010) The Preva-lence of Polycystic Ovary Syndrome in a Community Sample Assessed under Contrasting Diagnostic Criteria. Human Reproduction, 25, 544-551.
https://doi.org/10.1093/humrep/dep399 |
| [5] | Ramezani Tehrani, F. and Amiri, M. (2019) Polycystic Ovary Syn-drome in Adolescents: Challenges in Diagnosis and Treatment. International Journal of Endocrinology and Metabolism, 17, e91554. https://doi.org/10.5812/ijem.91554 |
| [6] | Rothenberg, S.S., Beverley, R., Barnard, E., et al. (2018) Polycystic Ovary Syndrome in Adolescents. Best Practice & Research Clinical Obstetrics & Gynaecology, 48, 103-114. https://doi.org/10.1016/j.bpobgyn.2017.08.008 |
| [7] | 宋颖, 李蓉. 多囊卵巢综合征中国诊疗指南解读[J]. 实用妇产科杂志, 2018, 34(10): 737-741. |
| [8] | Rosenfield, R.L., Ehrmann, D.A. and Littlejohn, E.E. (2015) Adolescent Polycystic Ovary Syndrome Due to Functional Ovarian Hyperandrogenism Persists into Adulthood. The Journal of Clinical Endocrinology & Metabolism, 100, 1537-1543. https://doi.org/10.1210/jc.2014-4290 |
| [9] | de Medeiros, S.F., de Medeiros, M.A.S., Barbosa, B.B., et al. (2021) Comparison of Metabolic and Obesity Biomarkers between Ad-olescent and Adult Women with Polycystic Ovary Syndrome. Archives of Gynecology and Obstetrics, 303, 739-749. https://doi.org/10.1007/s00404-020-05867-x |
| [10] | de Medeiros, S.F., Yamamoto, M.M.W., Souto de Medeiros, M.A., et al. (2020) Changes in Clinical and Biochemical Characteristics of Polycystic Ovary Syndrome with Advancing Age. Endocrine Connections, 9, 74-89.
https://doi.org/10.1530/EC-19-0496 |
| [11] | 金婧, 阮祥燕. 青春期多囊卵巢综合征的管理[J]. 中国临床医生杂志, 2021, 49(1): 14-17. |
| [12] | 周敏. 游离睾酮指数在多囊卵巢综合征患者中诊断价值的研究[D]: [硕士学位论文]. 重庆: 重庆医科大学, 2022. |
| [13] | Kamrul-Hasan, A., Aalpona, F.T.Z. and Selim, S. (2021) Clinical, Metabolic and Hormonal Profiles of Bangladeshi Adolescents with Polycystic Ovary Syndrome. touchREVIEWS in Endocrinology, 17, 54-58.
https://doi.org/10.17925/EE.2021.17.1.54 |
| [14] | Rackow, B.W., Vanden Brink, H., Hammers, L., et al. (2018) Ovarian Morphology by Transabdominal Ultrasound Correlates with Reproductive and Metabolic Disturbance in Ado-lescents with PCOS. Journal of Adolescent Health, 62, 288-293. https://doi.org/10.1016/j.jadohealth.2017.09.005 |
| [15] | Zore, T., Lizneva, D., Brakta, S., et al. (2019) Minimal Dif-ference in Phenotype between Adolescents and Young Adults with Polycystic Ovary Syndrome. Fertility and Sterility, 111, 389-396.
https://doi.org/10.1016/j.fertnstert.2018.10.020 |
| [16] | 谯小勇, 靳松, 杨业洲. 多囊卵巢综合征长期并发症早防早治新策略[J]. 中国计划生育和妇产科, 2020, 12(2): 13-18. |
| [17] | Fazleen, N.E., Whittaker, M. and Mamun, A. (2018) Risk of Metabolic Syndrome in Adolescents with Polycystic Ovarian Syndrome: A Systematic Review and Me-ta-Analysis. Diabetology & Metabolic Syndrome, 12, 1083-1090.
https://doi.org/10.1016/j.dsx.2018.03.014 |
| [18] | Coviello, A.D., Legro, R.S. and Dunaif, A. (2006) Adolescent Girls with Polycystic Ovary Syndrome Have an Increased Risk of the Metabolic Syndrome Associated with Increasing Androgen Levels Independent of Obesity and Insulin Resistance. The Journal of Clinical Endocrinology & Metabolism, 91, 492-497.
https://doi.org/10.1210/jc.2005-1666 |
| [19] | Harrison, C.L., Lombard, C.B., Moran, L.J. and Teede, H.J. (2011) Ex-ercise Therapy in Polycystic Ovary Syndrome: A Systematic Review. Human Reproduction Update, 17, 171-183. https://doi.org/10.1093/humupd/dmq045 |
| [20] | Ouchi, N., Kihara, S., Funahashi, T., et al. (2003) Reciprocal Asso-ciation of C-Reactive Protein with Adiponectin in Blood Stream and Adipose Tissue. Circulation, 107, 671-674. https://doi.org/10.1161/01.CIR.0000055188.83694.B3 |
