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糖尿病周围神经病变相关生物学标志物研究进展
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Abstract:
糖尿病周围神经病变(DPN)是糖尿病最常见的慢性并发症，起病隐匿可导致足部溃疡及疼痛、步态紊乱、坏疽，严重降低患者生活质量甚至导致截肢、致死，而当前尚无逆转方法。目前发病机制尚未明确，近年来各项研究表明，多种生物标志物参与DPN的发生发展，本文就对DPN相关的生物学标志物研究进展进行阐述，为DPN的诊断及治疗提供新方向。
Diabetic peripheral neuropathy (DPN) is the most common chronic complication of diabetes, which can lead to foot ulcers and pain, gait disorders, gangrene, seriously reducing the quality of life of pa-tients and even leading to amputation and death, and there is currently no way to reverse it. At present, the pathogenesis is not clear, and various studies in recent years have shown that a variety of biomarkers are involved in the occurrence and development of DPN, and this article elaborates on the research progress of DPN-related biological markers, which provides a new direction for the diagnosis and treatment of DPN.
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