茵陈五苓散加减治疗非酒精性脂肪性肝病的Meta分析
Meta-Analysis of Yinchen Wuling Powder in the Treatment of Non-Alcoholic Fatty Liver Disease

目的：系统评价茵陈五苓散加减治疗非酒精性脂肪性肝病(Nonalcoholic fatty liver disease, NAFLD)的临床疗效。方法：计算机检索中国知网、重庆维普全文、万方数据知识服务平台、中国生物医学文献服务系统和Pub Med、The Cochrane Library、EMbase，收集茵陈五苓散加减治疗NAFLD的随机对照试验(randomized controlled trial, RCT)，提取相关数据，用Cochrane对文献质量进行评价，用Rveman进行Meta分析。结果：纳入RCT文献9篇，共871例患者。Meta分析结果显示，治疗组用药有效率及改善肝功能、血脂异常方面优于对照组。结论：茵陈五苓散加减联合常规疗法治疗NAFLD效果优于单纯常规疗法。但本次纳入研究的文献数量、质量有限，使得该结论有待商榷，需更多高质量、大样本、多中心的RCT验证。
Objective: To evaluate the clinical efficacy of Yinchen Wuling powder in the treatment of Nonalcoholic fatty liver disease (NAFLD). Methods: China National Knowledge Infrastructure (CNKI), Chongqing VIP full text, Wanfang Data knowledge service platform, China Biomedical Literature Service System, Pub Med, The Cochrane Library, EMbase were searched by computer. Randomized controlled trials (RCT) of Yinchen Wuling powder in the treatment of NAFLD were collected, and the relevant data were extracted. Cochrane was used to evaluate the quality of the literature, and Rveman was used for meta-analysis. Results: Nine RCT articles were included, with a total of 871 patients. The results of meta-analysis showed that the effective rate and improvement of liver function and dyslipidemia in the treatment group were better than those in the control group. Conclusion: Yinchen Wuling powder combined with conventional therapy is better than conventional therapy in the treatment of NAFLD. However, due to the limited quantity and quality of the included studies, this conclusion is open to discussion, and more high-quality, large-sample and multicenter RCT verification is needed.