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植物乳杆菌R-15对高脂饮食下小鼠体质量及血脂的影响研究
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Abstract:
为研究植物乳杆菌R-15对高脂饮食小鼠体质量及血脂的影响，将40只成年洁净级雄性昆明小鼠随机分为普通组、高脂组、R-15-7d组和R-15-35d组等四组，其中普通组施喂基础饲料，高脂组施喂高脂饲料，R-15-7d组和R-15-35d组(施喂高脂饲料和R-15菌悬液)，检测小鼠体质量、脏器指数、血脂和血糖。结果显示：R-15-35d组在采食量相近的情况下，小鼠体质量增长最为缓慢(P < 0.05)。R-15对肝脏和肾脏指数影响较小(P > 0.05)，但可改善高脂饮食造成的脾脏指数增加(P < 0.05)；能显著抑制高脂饮食下小鼠血清总胆固醇和低密度脂蛋白胆固醇的升高(P < 0.05)，并降低小鼠动脉粥样硬化指数(P < 0.05)；对小鼠血糖有一定抑制作用，但差异不明显(P > 0.05)。
In order to study the effect of Lactobacillus plantarum R-15 on body weight and serum lipids of mice fed with high-fat, forty clean grade adult male Kunming mice were equivalently divided into four groups randomly, named normal group, high-fat group, R-15-7d group, and R-15-35d group individually. Among of them, mice of normal group were fed with basic feed, high-fat group were fed with high-fat feed, R-15-7d group and R-15-35d group were fed with high-fat feed and suspension of strain R-15. Finally, the body mass, organ index, blood lipids and glucose levels of mice in each group were measured. The results indicate that the body mass of mice in R-15-35d group increased most slowly under the con-dition of similar feed intake with other groups (P < 0.05). The strain R-15 had little effect on liver and kidney index (P > 0.05), but it could improve the increase of spleen index caused by high-fat diet (P < 0.05), and significantly inhibit the increase of serum total cholesterol and low density lip-oprotein cholesterol in mice under high-fat diet (P < 0.05), and reduce the atherosclerosis index of mice (P < 0.05), had a certain inhibitory effect on blood glucose in mice, but the difference is not ob-vious (P > 0.05).
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