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太子参提取物促透明质酸透皮吸收作用研究
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Abstract:
目的：采用体外透皮扩散试验探究太子参提取物对透明质酸(hyaluronic acid, HA)的透皮吸收促进作用。方法：利用改良型Franz扩散池考察HA的体外经皮渗透量变化，通过单位面积累计透过量及透皮吸收系数评价太子参提取物对HA透皮吸收的促进作用。结果：在体外透皮吸收实验中，透明质酸的单位面积累计透过量随时间变化线性递增，符合零级动力学方程。与传统的透皮吸收促进剂月桂氮酮相仿，太子参提取物对HA的透皮吸收起到积极的促进作用。结论：本研究对太子参提取物促HA透皮吸收作用进行了分析探索，为太子参在功能性护肤产品中的开发利用奠定基础。
Objective: Using in vitro diffusion cell method to explore the extract of Pseudostellaria Heterophylla to promote the absorption of hyaluronic acid (HA). Methods: Use the improved Franz diffusion cell to investigate the changes in HA’s transdermal absorption properties. Results: In the in vitro transdermal absorption experiment, the cumulative permeation amount per unit area of hyaluronic acid increased linearly with time, which conformed to the zero-order kinetic equation. Similar to the traditional transdermal absorption enhancer, lauroazone, the extract of Pseudostellaria Heterophylla has a positive effect on the transdermal absorption of HA. Conclusion: This study analyzed and explored the role of the extract of Pseudostellaria Heterophylla to the promotion of HA transparent skin, and laid the foundation for the development and utilization of Pseudostellaria Heterophylla in functional skin care products.
| [1] | Meyer, K. and Palmer, J.W. (1934) The Polysaccharide of the Vitreous Humor. Journal of Biological Chemistry, 107, 629-634. https://doi.org/10.1016/S0021-9258(18)75338-6 |
| [2] | 蔡同凯, 刘谋治, 邓婕, 等. 透明质酸的作用机制及临床应用研究进展[J]. 药学实践杂志, 2022, 40(2): 103-107. |
| [3] | 陆珊珊, 赵玉荣, 姚俊宏, 等. 中药挥发油透皮吸收促进剂制剂技术的研究进展[J]. 中草药, 2018, 49(10): 2477-2481. |
| [4] | Chen, J., Pang, W., Kan, Y., et al. (2017) Structure of a Pectic Polysaccharide from Pseudostellaria heterophylla and Stimulating Insulin Secretion of INS-1 Cell and Distributing in Rats by Oral. International Journal of Biological Macromolecules, 106, 456-463. https://doi.org/10.1016/j.ijbiomac.2017.08.034 |
| [5] | Chen, Y., Shen, Y., Guo, X., et al. (2006) Transdermal Protein Delivery by a Coadministered Peptide Identified via Phage Display. Nature Biotechnology, 24, 455-460. https://doi.org/10.1038/nbt1193 |
| [6] | 常明明. 阳离子环肽对胰岛素经皮和跨膜促渗作用研究[D]: [博士学位论文]. 大连: 大连理工大学, 2018. |
| [7] | 武晏屹, 田硕, 白明, 苗明三. 基于皮肤功能特点的药物透皮吸收新思考[J]. 世界中医药, 2020, 15(3): 361-363. |
| [8] | 庞晓晨, 成睿珍, 赵静, 等. 中药透皮给药系统研究进展及其新剂型的应用[J]. 中国新药杂志, 2019, 28(3): 286. |
| [9] | 应鹏云, 黄诗雨, 陈丽华, 等. 基于皮肤微生态环境中药挥发油作用特点分析[J]. 中成药, 2021, 43(8): 2141-2145. |
| [10] | 李倩, 高瑜, 邹佳, 等. 中药透皮吸收促进剂的研究进展[J]. 时珍国医国药, 2022, 33(1): 189-193. |
