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CSCs标志物在结直肠癌发生、发展中的研究
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Abstract:
CRC是全球最常见的癌症之一，目前CRC患者预后较差，其死亡与肿瘤侵袭和远处转移有着密切关系，寻找CRC治疗的新思路是亟待解决的问题。CSCs是恶性肿瘤中自我更新、具有多向分化潜能的细胞群，与恶性肿瘤的复发、转移、耐药等生物学行为密切相关；CSCs标志物的发现对结直肠癌的早发现、早诊治及预后评估具有重要意义。本文基于近年来国内外相关文献，就CSCs标志物在结直肠癌发生、发展过程中的研究进展作一综述，旨在为结直肠癌的靶向治疗提供参考。
Colorectal cancer is one of the most common cancers in the world. At present, the prognosis of colorectal cancer patients is poor. Its death is closely related to tumor invasion and distant metastasis. It is an urgent problem to find new ideas for the treatment of colorectal cancer. Cancer stem cells are self-renewal cells with multidirectional differentiation potential in malignant tumors, which are closely related to the biological behaviors of malignant tumors, such as recurrence, metastasis and drug resistance; The discovery of tumor stem cell markers is of great significance for the early detection, early diagnosis, treatment and prognosis of colorectal cancer. Based on the relevant literature at home and abroad in recent years, this paper reviews the research progress of tumor stem cell markers in the occurrence and development of colorectal cancer, in order to provide reference for the targeted treatment of colorectal cancer.
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