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胆固醇代谢途径中相关因子与非酒精性脂肪性肝病的研究
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Abstract:
非酒精性脂肪性肝病(非酒精性脂肪性肝炎为其严重的亚型)已为我国最常见的慢性肝脏疾病，其发病率仍逐年增加。目前，关于非酒精性脂肪性肝病的发病机制，被广泛认可的是“多重打击学说”，在该学说中的“胆固醇代谢”也被众多学者所关注。因此，本文结合近几年胆固醇代谢途径中相关因子对非酒精性脂肪性肝病的发病机制进行阐述，以期为该病的临床治疗及研究提供相关参考。
Non-alcoholic fatty liver disease (non-alcoholic steatohepatitis is its serious subtype) has been the most common chronic liver disease in China, and its incidence is still increasing year by year. At present, the pathogenesis of nonalcoholic fatty liver disease is widely recognized as the “multi-hit theory”, and the “cholesterol metabolism” in this theory has also been concerned by many scholars. Therefore, in this paper, the pathogenesis of nonalcoholic fatty liver disease is described in combination with the relevant factors in the cholesterol metabolic pathway in recent years in order to provide a relevant reference for the clinical treatment and research of the disease.
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