2018~2020年大理某医院粪肠球菌临床分布及耐药分析
Analysis of Clinical Distribution and Drug Resistance of Enterococcus faecalisin a Hospital of Dali from 2018 to 2020

目的：分析大理大学第一附属医院粪肠球菌感染分布特点、耐药性及其变化趋势，从而为临床治疗提供依据。方法：对大理大学第一附属医院2018年1月至2020年12月住院患者的各类标本进行分离培养和细菌鉴定、药敏试验和结果判定，对数据进行统计分析。结果：共分离182株粪肠球菌，标本主要来源于中段尿85株(46.70%)；科室主要来源于泌尿科66例(36.26%)；年龄在19~59岁患者的占比最多(56.04%)，其次为年龄在60岁以上的患者(38.46%)。药物呋喃妥因、利奈唑胺、替加环素、替考拉宁以及万古霉素可作为治疗我院肺粪肠球菌感染的一线药物。结论：随着临床上粪肠球菌感染率的逐渐增加以及抗菌药物的滥用，导致该菌检出率逐年增加，从而增加临床抗感染治疗的难度。目前医务人员需要做的是加强医院感染控制以及抗生素合理使用。
Objective: To analyze the distribution characteristics, drug resistance and its changing trend of Enterococcus faecalis infection in the First Affiliated Hospital of Dali University, so as to provide a basis for clinical treatment. Methods: Various specimens from inpatients of the First Affiliated Hospital of Dali University from January 2018 to December 2020 were isolated and cultured and bacterial identification, drug sensitivity tests and results were determined, and the data were statistically analyzed. Results: A total of 182 strains of Enterococcus faecalis were isolated, and the specimens mainly originated from 85 beads (46.70%) of middle urine; the department mainly originated from 66 cases (36.26%) of urology; patients aged 19~59 years accounted for the largest proportion (56.04%), and patients aged >60 years accounted for 38.46%. The drugs furantoin, linezolid, tigecycline, ticoranine, and vancomycin can be used as first-line drugs for the treatment of pulmonary Enterococcus faecalis infections in our hospital. Conclusion: With the gradual increase in the clinical rate of Enterococcus faecalis infection and the misuse of antimicrobial drugs, it leads to an increase in the detection rate of this organism year by year, thus increasing the difficulty of clinical anti-infective treatment. What medical personnel need to do now is to strengthen hospital infection control as well as the rational use of antibiotics.