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Pin1与膀胱癌发生的相关性
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Abstract:
Pin1是一种肽基–脯氨酰顺式/反式异构酶，属于PPIase家族，可特异性催化有丝分裂磷蛋白中磷酸丝氨酸–脯氨酸或苏氨酸–脯氨酸的酰胺键异构化，诱导其相互作用蛋白质的构象和功能变化。通过脯氨酰异构化，Pin1微调了关键磷蛋白的功能，影响了细胞生长周期调节、免疫反应、生殖细胞发育、神经元分化和存活以及癌症发生。已发现Pin1在许多癌症中过度表达。我们还通过分析Pin1参与Ras突变、Notch1通路和NF-KB通路等相互作用来检查Pin1在膀胱癌发生中的作用。本文主要就Pin1结构及功能进行简单介绍，对Pin1不同系统肿瘤中的表达及调控作用进行总结。最后，探索和讨论了Pin1与膀胱癌的相关性及其作用机制，为膀胱癌的治疗提供新思路、新靶点。
Pin1 peptide is a kind of base-preserved ammonia acyl cis/trans isomerase, belongs to the PPIase family, can specifically catalyze the isomerization of phosphoserine-proline or threonine-proline amide bonds in mitotic phosphoproteins, and induces conformational and functional changes in the interacting proteins. Through prolyl isomerization, Pin1 fine-tuned the function of key phosphoproteins, affecting cell growth cycle regulation, immune response, germ cell development, neuronal differentiation and survival, and carcinogenesis. Pin1 has been found to be overexpressed in many cancers. We also examined the role of Pin1 in bladder cancer development by analyzing the interactions of Pin1 in RAS mutation, Notch1 pathway, and NF-KB pathway. In this paper, the structure and function of Pin1 were briefly introduced, and the expression and regulation of Pin1 in different tumor systems were summarized. Finally, the correlation between Pin1 and bladder cancer and its mechanism of action were explored and discussed, providing new ideas and new targets for the treatment of bladder cancer.
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