|
|
血清IgE在哮喘和慢性阻塞性肺疾病进展中的作用
|
Abstract:
哮喘和慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是两种常见的、以慢性气道炎症为主要特征的呼吸系统疾病。相关研究发现，IgE (immunoglobulin E)在哮喘和COPD的疾病进展中都起着重要作用，因为它与两种疾病的呼吸道症状、肺功能、细菌和病毒感染、气道重塑和支气管反应性相关。本文通过对相关研究的整理，分析IgE (包括特异性IgE和总IgE)在COPD和哮喘中的作用，探寻两种疾病在治疗方式上的异同。
Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway inflammatory diseases. IgE production appears to play an important role in the development of both COPD and asthma, as it has been associated with respiratory symptoms, lung function, bacterial and viral infections, airway remodeling and bronchial hyperreactivity in both diseases. The aim of this review is to summarize all current data concerning the role of specific and total IgE in COPD and asthma and to highlight similarities and differences in view of possible therapeutic interventions.
| [1] | 唐先发. 特应性疾病共同易感位点及其交互作用研究[D]: [硕士学位论文]. 合肥: 安徽医科大学, 2012. |
| [2] | George, L. and Brightling, C.E. (2016) Eosinophilic Airway Inflammation: Role in Asthma and Chronic Obstructive Pulmonary Disease. Therapeutic Advances in Chronic Disease, 7, 34-51. https://doi.org/10.1177/2040622315609251 |
| [3] | Albertson, T.E., Chenoweth, J.A., Pearson, S.J. and Murin, S. (2020) The Pharmacological Management of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome (ACOS). Expert Opinion on Pharmacotherapy, 21, 213-231. https://doi.org/10.1080/14656566.2019.1701656 |
| [4] | Romanet-Manent, S., Charpin, D., Magnan, A., Lanteaume, A. and Vervloet, D. (2002) Allergic vs. Nonallergic Asthma: What Makes the Difference. Allergy, 57, 607-613. https://doi.org/10.1034/j.1398-9995.2002.23504.x |
| [5] | Virdkow, J.-C., Kroegel, C., Walker, C. and Matthys, H. (1994) Cellular and Immunological Markers of Allergic and Intrinsic Bronchial Asthma. Lung, 172, 313-314. https://doi.org/10.1007/BF00172846 |
| [6] | Putcha, N., Fawzy, A., Matsui, E., Liu, M., Bowler, R., Woodruff, P., et al. (2020) Clinical Phenotypes of Atopy and Asthma in COPD: A Meta-Analysis of SPIROMICS and COPD Gene. Chest, 158, 2333-2345. |
| [7] | Tiew, P.Y., Ko, F.W.S., Pang, S.L., Matta, S.A., Sio, Y.Y., Poh, M.E., et al. (2020) Environmental Fungal Sensitisation Associates with Poorer Clinical Outcomes in COPD. European Respiratory Journal, 56, Article ID: 2000418.
https://doi.org/10.1183/13993003.00418-2020 |
| [8] | Singh, B., Arora, S. and Khanna, V. (2010) Association of Severity of COPD with IgE and Interleukin-1 Beta. Monaldi Archives for Chest Disease, 73, 86-87. https://doi.org/10.4081/monaldi.2010.303 |
| [9] | Sluiter, H.J., Koeter, G.H., de Monchy, J.G., Postma, D.S., de Vries, K. and Orie, N.G. (1991) The Dutch Hypothesis (Chronic Non-Specific Lung Disease) Revisited. European Respiratory Journal, 4, 479-489. |
| [10] | Christenson, S.A., Steiling, K., van den Berge, M., et al. (2015) Asthma-COPD Overlap. Clinical Relevance of Genomic Signatures of Type 2 Inflammation in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, 191, 758-766. https://doi.org/10.1164/rccm.201408-1458OC |
| [11] | Bozek, A. and Rogala, B. (2018) IgE-Dependent Sensitization in Patients with COPD. Annals of Agricultural and Environmental Medicine, 25, 417-420. https://doi.org/10.26444/aaem/83413 |
| [12] | Sigurs, N.A. (2002) Cohort of Children Hospitalised with Acute RSV Bronchiolitis: Impact on Later Respiratory Disease. Paediatric Respiratory Reviews, 3, 177-183. https://doi.org/10.1016/S1526-0542(02)00191-4 |
| [13] | Tam, J.S., Jackson, W.T., Hunter, D., Proud, D. and Grayson, M.H. (2013) Rhinovirus Specific IgE Can Be Detected in Human Sera. Journal of Allergy and Clinical Immunology, 132, 1241-1243.
https://doi.org/10.1016/j.jaci.2013.07.011 |
| [14] | van Rijt, L.S., van Kessel, C.H., Boogaard, I. and Lambrecht, B.N. (2005) Respiratory Viral Infections and Asthma Pathogenesis: A Critical Role for Dendritic Cells? Journal of Clinical Virology, 34, 161-169.
https://doi.org/10.1016/j.jcv.2005.07.002 |
| [15] | Koraka, P., Murgue, B., Deparis, X., et al. (2003) Elevated Levels of Total and Dengue Virus-Specific Immunoglobulin E in Patients with Varying Disease Severity. Journal of Medical Virology, 70, 91-98.
https://doi.org/10.1002/jmv.10358 |
| [16] | Sigurs, N. (2001) Epidemiologic and Clinical Evidence of a Respiratory Syncytial Virus-Reactive Airway Disease Link. American Journal of Respiratory and Critical Care Medicine, 163, S2-S6.
https://doi.org/10.1164/ajrccm.163.supplement_1.2011109 |
| [17] | Welliver, R.C. and Duffy, L. (1993) The Relationship of RSV-Specific Immunoglobulin E Antibody Responses in Infancy, Recurrent Wheezing, and Pulmonary Function at Age 7-8 Years. Pediatric Pulmonology, 15, 19-27.
https://doi.org/10.1002/ppul.1950150104 |
| [18] | Sigurs, N., Bjarnason, R., Sigurbergsson, F., Kjellman, B. and Bjorksten, B. (1995) Asthma and Immunoglobulin E Antibodies after Respiratory syncytial Virus Bronchiolitis: A Prospective Cohort Study with Matched Controls. Pediatrics, 95, 500-505. |
| [19] | Kristjansson, S., Bjarnarson, S.P., Wennergren, G., et al. (2005) Respiratory Syncytial Virus and Other Respiratory Viruses during the First 3 Months of Life Promote a Local TH2-Like Response. Journal of Allergy and Clinical Immunology, 116, 805-811. https://doi.org/10.1016/j.jaci.2005.07.012 |
| [20] | Carroll, K.N., Wu, P., Gebretsadik, T., et al. (2009) Season of Infant Bronchiolitis and Estimates of Subsequent Risk and Burden of Early Childhood Asthma. Journal of Allergy and Clinical Immunology, 123, 964-966.
https://doi.org/10.1016/j.jaci.2008.12.011 |
| [21] | Wu, P., Dupont, W.D., Griffin, M.R., et al. (2008) Evidence of a Causal Role of Winter Virus Infection during Infancy in Early childhood Asthma. American Journal of Respiratory and Critical Care Medicine, 178, 1123-1129.
https://doi.org/10.1164/rccm.200804-579OC |
| [22] | Kim, E.Y., Battaile, J.T., Patel, A.C., You, Y., Agapov, E., Grayson, M.H., et al. (2008) Persistent Activation of an Innate Immune Response Translates Respiratory Viral Infection into Chronic Lung Disease. Nature Medicine, 14, 633-640. https://doi.org/10.1038/nm1770 |
| [23] | Aaron, S.D., Donaldson, G.C., Whitmore, G.A., et al. (2012) Time Course and Pattern of COPD Exacerbation Onset. Thorax, 67, 238-243. https://doi.org/10.1136/thoraxjnl-2011-200768 |
| [24] | Hurst, J.R., Donaldson, G.C., Wilkinson, T.M., et al. (2005) Epidemiological Relationships between the Common Cold and Exacerbation Frequency in COPD. European Respiratory Journal, 26, 846-852.
https://doi.org/10.1183/09031936.05.00043405 |
| [25] | Johnston, N.W., Olsson, M., Edsbacker, S., et al. (2017) Colds as Predictors of the Onset and Severity of COPD Exacerbations. International Journal of Chronic Obstructive Pulmonary Disease, 12, 839-848.
https://doi.org/10.2147/COPD.S127146 |
| [26] | Iikura, M., Hojo, M., Koketsu, R., et al. (2015) The Importance of Bacterial and Viral Infections Associated with Adult Asthma Exacerbations in Clinical Practice. PLoS ONE, 10, e0123584. https://doi.org/10.1371/journal.pone.0123584 |
| [27] | Balaban, N. and Rasooly, A. (2000) Staphylococcal Enterotoxins. International Journal of Food Microbiology, 61, 1-10. https://doi.org/10.1016/S0168-1605(00)00377-9 |
| [28] | Huvenne, W., Hellings, P.W. and Bachert, C. (2013) Role of Staphylococcal Superantigens in Airway Disease. International Archives of Allergy and Immunology, 161, 304-314. https://doi.org/10.1159/000350329 |
| [29] | Bachert, C. and Zhang, N. (2012) Chronic Rhinosinusitis and Asthma: Novel Understanding of the Role of IgE “Above Atopy”. Journal of Internal Medicine, 272, 133-143. https://doi.org/10.1111/j.1365-2796.2012.02559.x |
| [30] | Sachse, F., Becker, K., von Eiff, C., Metze, D. and Rudack, C. (2010) Staphylococcus aureus Invades the Epithelium in Nasal Polyposis and Induces IL-6 in Nasal Epithelial Cells In Vitro. Allergy, 65, 1430-1437.
https://doi.org/10.1111/j.1398-9995.2010.02381.x |
| [31] | Nakamura, Y., Oscherwitz, J., Cease, K.B., Chan, S.M., Munoz-Planillo, R., Hasegawa, M., et al. (2013) Staphylococcus Delta-Toxin Induces Allergic Skin Disease by Activating Mast Cells. Nature, 503, 397-401.
https://doi.org/10.1038/nature12655 |
| [32] | Teufelberger, A.R., Nordengrun, M., Braun, H., et al. (2018) The IL-33/ST2 Axis Is Crucial in Type 2 Airway Responses Induced by Staphylococcus aureus-Derived Serine Protease-Like Protein D. Journal of Allergy and Clinical Immunology, 141, 549-559.e7. https://doi.org/10.1016/j.jaci.2017.05.004 |
| [33] | Kim, S.H., Yang, S.Y., You, J., et al. (2016) Association of Specific Immunoglobulin E to Staphylococcal Enterotoxin with Airway Hyperresponsiveness in Asthma Patients. Tuberculosis and Respiratory Diseases, 79, 295-301.
https://doi.org/10.4046/trd.2016.79.4.295 |
| [34] | Martorano, L.M. and Grayson, M.H. (2018) Respiratory Viral Infections and Atopic Development: From Possible Mechanisms to Advances in Treatment. European Journal of Immunology, 48, 407-414.
https://doi.org/10.1002/eji.201747052 |
| [35] | Roth, M., Zhong, J., Zumkeller, C., S’Ng, C.T., Goulet, S. and Tamm, M. (2013) The Role of IgE-Receptors in IgE-Dependent Airway Smooth Muscle Cell Remodelling. PLoS ONE, 8, e56015.
https://doi.org/10.1371/journal.pone.0056015 |
| [36] | Roth, M., Zhao, F., Zhong, J., Lardinois, D. and Tamm, M. (2015) Serum IgE Induced Airway Smooth Muscle Cell Remodeling Is Independent of Allergens and Is Prevented by Omalizumab. PLoS ONE, 10, e0136549.
https://doi.org/10.1371/journal.pone.0136549 |
| [37] | Aubier, M. (2010) Severe Asthma: New Therapeutic Targets. Bulletin de L’Académie Nationale de Médecine, 194, 1009-1019. https://doi.org/10.1016/S0001-4079(19)32230-7 |
| [38] | Deurloo, D.T., van Berkel, M.A., van Esch, B.C., et al. (2003) CD28/CILA4 Double Deficient Mice Demonstrate Crucial role for Er7 Costimulation in the Induction of Allergic Lower Airways Dim. Clinical & Experimental Allergy, 33, 1297-1304. https://doi.org/10.1046/j.1365-2222.2003.01757.x |
| [39] | Tan, J., Wang, L., He, Y. and Chen, L. (2006) All Roads Lead to Rome: Pathways of NKT Cells Promoting Asthma. Archivum Immunologiae et Therapiae Experimentalis (Warsz), 54, 335-340.
https://doi.org/10.1007/s00005-006-0041-z |
| [40] | Papakonstantinou, E., Savic, S., Siebeneichler, A., et al. (2019) Pilot Study to Test the Feasibility of Histological Characterisation of Asthma-COPD Overlap. European Respiratory Journal, 53, Article ID: 1801941.
https://doi.org/10.1183/13993003.01941-2018 |
| [41] | 张景鸿, 李超乾. 支气管哮喘气道高反应性机制的研究进展[J]. 中国呼吸与危重监护杂志, 2011, 10(3): 304-307. |
| [42] | 刘岩, 孙铁英, 张洪胜, 李佩珍. 哮喘与慢性阻塞性肺疾病气道反应性研究[J]. 中国医刊, 2006, 41(1): 36-37. |
