|
|
妊娠期人乳头瘤病毒感染的管理
|
Abstract:
人乳头瘤病毒(Human papillomavirus, HPV)是女性生殖道感染最常见的病毒之一，低危型HPV感染与生殖道湿疣相关，而高危型HPV感染是导致宫颈癌的主要原因。妊娠期妇女HPV感染不仅威胁着母体本身健康，同时对于妊娠结局、分娩方式及新生儿的状况也具有一定影响。目前由于HPV疫苗在我国获批年限短且接种率低，难以实现有效的宫颈癌一级预防，所以备孕期或妊娠期女性HPV病毒检测对于降低妊娠期女性宫颈癌的发病率及响应优生优育政策是十分必要的。
Human papillomavirus (HPV) is one of the most common viruses in female genital tract infection. Low-risk HPV infection is related to genital condyloma, and high-risk HPV infection is the main cause of cervical cancer. HPV infection in pregnant women not only threatens the health of the mother, but also has a certain impact on the outcome of pregnancy, the mode of delivery and the status of newborns. At present, because the HPV vaccine is short in China and the vaccination rate is low, it is difficult to achieve effective primary prevention of cervical cancer. Therefore, detection of HPV virus in pregnant women or pregnant women is very necessary for reducing the incidence rate of cervical cancer and the policy of eugenics and prenatal care in pregnant women.
| [1] | Gaffney, D.K., Hashibe, M., Kepka, D., et al. (2018) Too Many Women Are Dying from Cervix Cancer: Problems and Solutions. Gynecologic Oncology, 151, 547-554. https://doi.org/10.1016/j.ygyno.2018.10.004 |
| [2] | Hunter, M.I., Tewari, K. and Monk, B.J. (2008) Cervical Neoplasia in Pregnancy. Part 2: Current Treatment of Invasive Disease. American Journal of Obstetrics and Gynecology, 199, 10-18. https://doi.org/10.1016/j.ajog.2007.12.011 |
| [3] | 王宇, 宋淑芳, 刘凤. 我国宫颈癌流行病学特征和发病高危因素的研究进展[J]. 中国妇幼保健, 2019, 34(5): 1207-1209. |
| [4] | 谢锋, 李笑天. 人乳头瘤病毒感染与妊娠[J]. 实用妇产科杂志, 2018, 34(12): 897-899. |
| [5] | 杨淑哲, 王文娟, 邓耀, 贺苇军. 我国大陆妊娠期女性HPV感染情况分析[J]. 中国计划生育学杂志, 2017, 25(6): 364-368. |
| [6] | Pandey, D., et al. (2019) Human Papillomavirus (HPV) Infection in Early Pregnancy: Prevalence and Implications. Infectious Diseases in Obstetrics and Gynecology, 2019, 1-5. https://doi.org/10.1155/2019/4376902 |
| [7] | Schulze, M.H., et al. (2016) High Prevalence of Human Papillomaviruses in Ghanaian Pregnant Women. Medical Microbiology and Immunology, 205, 595-602. https://doi.org/10.1007/s00430-016-0475-9 |
| [8] | Salcedo, M., et al. (2015) Prevalence of Human Papillomavirus Infection in Pregnant versus Non-Pregnant Women in Brazil. Archives of Gynecology and Obstetrics, 292, 1273-1278. https://doi.org/10.1007/s00404-015-3752-8 |
| [9] | Liu, P., et al. (2014) The Prevalence and Risk of Human Papillomavirus Infection in Pregnant Women. Epidemiology and Infection, 142, 1567-1578. https://doi.org/10.1017/S0950268814000636 |
| [10] | 纪巍, 张晓瑜, 张邂方. 1763例妊娠期女性宫颈HPV感染情况分析[J]. 检验医学与临床, 2018, 15(20): 3041-3042+3045. |
| [11] | 余艳琴, 富诗岚, 徐慧芳, 韦梦娜, 陈琦, 胡尚英, 赵方辉, 乔友林. 中国大陆女性体检人群中人乳头瘤病毒型别感染率及九价疫苗中HPV各型别分布的系统评价[J]. 肿瘤预防与治疗, 2019, 32(2): 103-113. |
| [12] | Trottier, H., Mahmud, S., Costa, M.C., et al. (2016) Human Papillomavirus Infections with Multiple Types and Risk of Cervical Neoplasia. Cancer Epidemiology, Biomarkers & Prevention, 15, 1274-1280.
https://doi.org/10.1158/1055-9965.EPI-06-0129 |
| [13] | Cunningham, F.C., Leveno, K.J., et al. (2014) Williams Obstetrics. 24th Edition, 1291. |
| [14] | 卢丹华, 王颖楠, 石展鹰, 赵敏, 张丹宁. 不同妊娠期孕妇人乳头瘤病毒感染情况及对母婴结局的影响[J]. 中华医院感染学杂志, 2017, 27(15): 3552-3554+3570. |
| [15] | Grce, M., Husnjak, K., Matovina, M., et al. (2004) Human Papillomavirus, Cytomegalovirus, and Adeno-Associated Virus Infections in Pregnant and Nonpregnant Women with Cervical Intraepithelial Neoplasia. Journal of Clinical Microbiology, 42, 1341-1344. https://doi.org/10.1128/JCM.42.3.1341-1344.2004 |
| [16] | 卢丹妮, 张为远. 人乳头瘤病毒感染对母婴健康影响的研究进展[J]. 中国计划生育和妇产科, 2017, 9(5): 26-28+35. |
| [17] | Lukasz, B., et al. (2019) Influence of Human Papilloma Virus (hPV) Infection on Early Pregnancy. Ginekologia Polska, 90, 72-75. https://doi.org/10.5603/GP.2019.0012 |
| [18] | Xiong, Y.-Q., et al. (2018) The Risk of Human Papillomavirus Infection for Spontaneous Abortion, Spontaneous Preterm Birth, and Pregnancy Rate of Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis. Gynecologic and Obstetric Investigation, 83, 417-427. https://doi.org/10.1159/000482008 |
| [19] | 冯磊, 王瑛, 陈红, 张蓉. 宫外孕与人乳头瘤病毒(HPV)相关性分析[J]. 中国实验诊断学, 2018, 22(7): 1216-1217. |
| [20] | 金海红, 赖筱琍, 余军辉. 妊娠期女性人乳头瘤病毒感染分型及其对产后并发症和新生儿近期状况的影响[J]. 中国病毒病杂志, 2020, 10(2): 137-141. |
| [21] | 徐文. 高危型人乳头瘤病毒感染与不良妊娠结局相关性的Meta-分析[D]: [硕士学位论文]. 长春: 吉林大学, 2019. |
| [22] | 廖燕, 张淑珍, 赵红艳, 毛雪梅, 武丽红. 妊娠晚期HPV感染孕产妇阴道炎发生率及妊娠结局的影响分析[J]. 中华医院感染学杂志, 2017, 27(23): 5460-5463. |
| [23] | 文蛟龙, 粱德育, 陈元花. 妊娠期HPV病毒感染分型及对妊娠结局的影响[J]. 临床血液学杂志(输血与检验), 2020, 33(4): 268-271. |
| [24] | Nadarzynski, T., et al. (2018) Men Who Have Sex with Men Who Do Not Access Sexual Health Clinics Nor Disclose Sexual Orientation Are Unlikely to Receive the HPV Vaccine in the UK. Vaccine, 36, 5065-5070.
https://doi.org/10.1016/j.vaccine.2018.06.075 |
| [25] | Zouridis, A., et al. (2018) Intrauterine HPV Transmission: A Systematic Review of the Literature. Archives of Gynecology and Obstetrics, 298, 35-44. https://doi.org/10.1007/s00404-018-4787-4 |
| [26] | Perkins, R.B., et al. (2020) 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors. Journal of Lower Genital Tract Disease, 24, 102-131.
https://doi.org/10.1097/LGT.0000000000000525 |
