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- 2019
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell AgingDOI: https://doi.org/10.1016/j.celrep.2018.12.101 Abstract: ？ SIRT2 is required for HSC maintenance at an old but not young age ？ SIRT2 represses the activation of the NLRP3 inflammasome in HSCs ？ NLRP3 inflammasome is activated in aged HSCs due to increased mitochondrial stress ？ SIRT2 activation, NLRP3 inactivation, or caspase 1 inactivation reverses HSC agin
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