橙皮素芳酰腙化合物的微波合成与抑菌活性研究
The Study on Microwave Synthesis and Antibacterial Activity of Hesperetin Aromatic Hydrazone Compounds

利用微波辐射技术,以橙皮素和芳酰肼为原料设计合成3种橙皮素芳酰腙类化合物,应用红外光谱、核磁共振谱、质谱和元素分析等分析手段对化合物进行了结构表征.抑菌活性实验表明,合成的3种橙皮素芳酰腙类化合物对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌的抑菌活性与橙皮素相比均有较大增强.
Three hesperetin aromatic hydrazone compounds are synthesized in good yields under microwave irradiation by reaction of hesperetin with hydrazides. The structures of these compounds are confirmed by IR, 1H NMR, MS spectra and elemental analysis. Inhibition test showed that the hesperetin aromatic hydrazone compounds against Escherichia coli, Staphylococcus aureus and Bacillus subtilis have good antibacterial activity, compared with hesperetin, have a greater enhancement of antibacterial activity