|
乙酰左旋肉碱的神经保护作用最新研究进展
|
Abstract:
[1] | Huang, Z., et al. (2019) Metabolomics Reveals the Role of Acetyl-L-Carnitine Metabolism in γ-FeO NP-Induced Embryonic Development Toxicity via Mitochondria Damage. Nanotoxicology, 13, 204-220.
https://doi.org/10.1080/17435390.2018.1537411 |
[2] | Bodaghi-Namileh, V., et al. (2018) Acetyl-L-Carnitine Attenuates Arsenic-Induced Liver Injury by Abrogation of Mitochondrial Dysfunction, Inflammation, and Apoptosis in Rats. Environmental Toxicology and Pharmacology, 58, 11-20. https://doi.org/10.1016/j.etap.2017.12.005 |
[3] | Pesce, V., Nicassio, L., Fracasso, F., et al. (2012) Acetyl-L-Carnitine Activates the Peroxisome Proliferator-Activated Receptor-Gamma Coactivators PGC-1alpha/PGC-1beta-Dependent Signaling Cascade of Mitochondrial Biogenesis and Decreases the Oxidized Peroxiredoxins Content in Old Rat Liver. Rejuvenation Research,, 15, 136-139.
https://doi.org/10.1089/rej.2011.1255 |
[4] | Aliev, G., Liu, J., Shenk, J.C., et al. (2009) Neuronal Mitochondrial Amelioration by Feeding Acetyl-L-Carnitine and Lipoic Acid to Aged Rats. Journal of Cellular and Molecular Medicine, 13, 320-333.
https://doi.org/10.1111/j.1582-4934.2008.00324.x |
[5] | La, G., Sh, H. and Tm, H. (2012) Acetyl-L-Carnitine Supplementation Reverses the Age-Related Decline in Carnitine Palmitoyltransferase 1 (CPT1) Activity in Interfibrillar Mitochondria without Changing the L-Carnitine Content in the Rat Heart. Mechanisms of Ageing and Development, 133, 99-106. https://doi.org/10.1016/j.mad.2012.01.007 |
[6] | Singh, M., et al. (2018) Age-Related Defects in Short-Term Plasticity Are Reversed by Acetyl-L-Carnitine at the Mouse Calyx of Held. Neurobiology of Aging, 67, 108-119. https://doi.org/10.1016/j.neurobiolaging.2018.03.015 |
[7] | Mehrotra, A., et al. (2015) Mitochondrial Modulators Improve Lipid Composition and Attenuate Memory Deficits in Experimental Model of Huntington’s Disease. Molecular and Cellular Biochemistry, 410, 281-292.
https://doi.org/10.1007/s11010-015-2561-5 |
[8] | Xu, H.Y., et al. (2019) Maturation of Buffalo Oocytes in Vitro with Acetyl-L-Carnitine Improves Cryotolerance Due to Changes in Mitochondrial Function and the Membrane Lipid Profile. Reproduction, Fertility, and Development, 31, 386-394. https://doi.org/10.1071/RD18102 |
[9] | Farooqui, A.A., Horrocks, L.A. and Farooqui, T. (2007) Modulation of Inflammation in Brain: A Matter of Fat. Journal of Neurochemistry, 101, 577-599. https://doi.org/10.1111/j.1471-4159.2006.04371.x |
[10] | Horrocks, L.A. and Farooqui, A.A. (2004) Docosahexaenoic Acid in the Diet: Its Importance in Maintenance and Restoration of Neural Membrane Function. Prostaglandins, Leukotrienes & Essential Fatty Acids, 70, 361-372.
https://doi.org/10.1016/j.plefa.2003.12.011 |
[11] | Shea, T.B. (2019) Choline and Phosphatidylcholine May Maintain Cognitive Performance by Multiple Mechanisms. The American Journal of Clinical Nutrition, 110, 1268-1269. https://doi.org/10.1093/ajcn/nqz244 |
[12] | Hao, Y., et al. (2020) Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment. Frontiers in Molecular Neuroscience, 13, 58.
https://doi.org/10.3389/fnmol.2020.00058 |
[13] | Mohammad-Bagher, G., et al. (2019) Synergistic Effects of Acetyl-L-Carnitine and Adipose-Derived Stromal Cells on Improving Regenerative Capacity of Acellular Nerve Allograft in Sciatic Nerve Defect. The Journal of Pharmacology and Experimental Therapeutics, 368, 490-502. https://doi.org/10.1124/jpet.118.254540 |
[14] | Rolim, L.C.S.P., et al. (2019) Acetyl-L-Carnitine for the Treatment of Diabetic Peripheral Neuropathy. The Cochrane Database of Systematic Reviews, 6, D11265. |
[15] | Kobayashi, S., et al. (2010) Acetyl-L-Carnitine Improves Aged Brain Function. Geriatrics & Gerontology International, S99-S106. https://doi.org/10.1111/j.1447-0594.2010.00595.x |
[16] | Schroeder, M.A., et al. (2012) The Cycling of Acetyl-Coenzyme A through Acetylcarnitine Buffers Cardiac Substrate Supply: A Hyperpolarized 13C Magnetic Resonance Study. Circulation. Cardiovascular Imaging, 5, 201-209.
https://doi.org/10.1161/CIRCIMAGING.111.969451 |
[17] | Scafidi, S., et al. (2010) Neuroprotection by Acetyl-L-Carnitine after Traumatic Injury to the Immature Rat Brain. Developmental Neuroscience, 32, 480-487. |
[18] | Afshin-Majd, S., et al. (2017) Acetyl-L-Carnitine Protects Dopaminergic Nigrostriatal Pathway in 6-Hydroxydopa- mine-Induced Model of Parkinson’s Disease in the Rat. Biomedicine & Pharmacotherapy, 89, 1-9.
https://doi.org/10.1016/j.biopha.2017.02.007 |
[19] | Singh, S., et al. (2018) Acetyl-L-Carnitine via Upegulating Dopamine D1 Receptor and Attenuating Microglial Activation Prevents Neuronal Loss and Improves Memory Functions in Parkinsonian Rats. Molecular Neurobiology, 55, 583-602. https://doi.org/10.1007/s12035-016-0293-5 |
[20] | Hota, K.B., Hota, S.K., Chaurasia, O.P., et al. (2012) Acetyl-L-Carnitine-Mediated Neuroprotection during Hypoxia Is Attributed to ERK1/2-Nrf2-Regulated Mitochondrial Biosynthesis. Hippocampus, 22, 723-736.
https://doi.org/10.1002/hipo.20934 |
[21] | Calabrese, V., Ravagna, A., Colombrita, C., et al. (2005) Acetylcarnitine Induces Heme Oxygenase in Rat Astrocytes and Protects against Oxidative Stress: Involvement of the Transcription Factor Nrf2. Journal of Neuroscience Research, 79, 509-521. https://doi.org/10.1002/jnr.20386 |
[22] | Arrigoni-Martelli, E. and Caso, V. (2001) Carnitine Protects Mitochondria and Removes Toxic Acyls from Xenobiotics Drugs. Experimental and Clinical Research, 27, 27-49. |
[23] | Pillich, R.T., Scarsella, G. and Risuleo, G. (2005) Reduction of Apoptosis through the Mitochondrial Pathway by the Administration of Acetyl-L-Carnitine to Mouse Fibroblasts in Culture. Experimental Cell Research, 306, 1-8.
https://doi.org/10.1016/j.yexcr.2005.01.019 |
[24] | Altun, Z., Olgun, Y., Ercetin, P., et al. (2014) Protective Effect of Acetyl-L-Carnitine against Cisplatin Ototoxicity: Role of Apoptosis-Related Genes and Pro-Inflammatory Cytokines. Cell Proliferation, 47, 72-80.
https://doi.org/10.1111/cpr.12080 |
[25] | Di Cesare, M.L., Ghelardini, C., Calvani, M., et al. (2007) Protective Effect of Acetyl-L-Carnitine on the Apoptotic Pathway of Peripheral Neuropathy. European Journal of Neuroscience, 26, 820-827.
https://doi.org/10.1111/j.1460-9568.2007.05722.x |
[26] | Traina, G., Bernardi, R., Rizzo, M., et al. (2006) Acetyl-L-Carnitine Up-Regulates Expression of Voltage-Dependent Anion Channel in the Rat Brain. Neurochemistry International, 48, 673-678.
https://doi.org/10.1016/j.neuint.2005.11.005 |
[27] | Traina, G., Bernardi, R., Cataldo, E., et al. (2008) In the Rat Brain Acetyl-L-Carnitine Treatment Modulates the Expression of Genes Involved in Neuronal Ceroid Lipofuscinosis. Molecular Neurobiology, 38, 146-152.
https://doi.org/10.1007/s12035-008-8038-8 |
[28] | Steiber, A., Kerner, J. and Hoppel, C.L. (2004) Carnitine: A Nutritional, Biosynthetic, and Functional Perspective. Molecular Aspects of Medicine, 25, 455-473. https://doi.org/10.1016/j.mam.2004.06.006 |
[29] | Cassano, P., Sciancalepore, A.G., Pesce, V., et al. (2006) Acetyl-L-Carnitine Feeding to Unloaded Rats Triggers in Soleus Muscle the Coordinated Expression of Genes Involved in Mitochondrial Biogenesis. Biochimica et Biophysica Acta, 1757, 1421-1428. https://doi.org/10.1016/j.bbabio.2006.05.019 |
[30] | Chiechio, S., Caricasole, A., Barletta, E., et al. (2002) L-Acetylcarnitine Induces Analgesia by Selectively Up-Regulating mGlu2 Metabotropic Glutamate Receptors. Molecular Pharmacology, 61, 989-996. https://doi.org/10.1124/mol.61.5.989 |
[31] | Chiechio, S., Copani, A., De Petris, L., et al. (2006) Transcriptional Regulation of Metabotropic Glutamate Receptor 2/3 Expression by the NF-kappaB Pathway in Primary Dorsal Root Ganglia Neurons: A Possible Mechanism for the Analgesic Effect of L-Acetylcarnitine. Molecular Pain, 2, 20. https://doi.org/10.1186/1744-8069-2-20 |
[32] | Di Cesare Mannelli, L., et al. (2009) Neuroprotective Effects of Acetyl-L-Carnitine on Neuropathic Pain and Apoptosis: A Role for the Nicotinic Receptor. Journal of Neuroscience Research, 87, 200-207.
https://doi.org/10.1002/jnr.21815 |
[33] | Li, S., et al. (2014) Acetyl-L-Carnitine for the Treatment of Peripheral Neuropathic Pain: A Systematic Review and Meta-Analysis. Value in Health, 17, A810. https://doi.org/10.1016/j.jval.2014.08.545 |
[34] | Di Stefano, G., Di Lionardo, A., Galosi, E., et al. (2019) Acetyl-L-Carnitine in Painful Peripheral Neuropathy: A Systematic Review. Journal of Pain Research, 12, 1341-1351. https://doi.org/10.2147/JPR.S190231 |
[35] | Tomassoni, D., et al. (2018) Treatment with Acetyl-L-Carnitine Exerts a Neuroprotective Effect in the Sciatic Nerve Following Loose Ligation: A Functional and Microanatomical Study. Neural Regeneration Research, 13, 692-698.
https://doi.org/10.4103/1673-5374.230297 |
[36] | Nasca, C., Xenos, D., Barone, Y., et al. (2013) L-Acetylcarnitine Causes Rapid Antidepressant Effects through the Epigenetic Induction of mGlu2 Receptors. Proceedings of the National Academy of Sciences of the United States of America, 110, 4804-4809. https://doi.org/10.1073/pnas.1216100110 |
[37] | Pancotto, L., et al. (2018) Anxiolytic and Anti-Stress Effects of Acute Administration of Acetyl-L-Carnitine in Zebrafish. PeerJ, 6, e5309. https://doi.org/10.7717/peerj.5309 |