中年人群中冠状动脉慢血流与阻塞性睡眠呼吸暂停综合征的相关性分析
Correlation between Coronary Slow Flow and Obstructive Sleep Apnea Syndrome in Middle-Aged Patients

目的：探究中年人群中冠状动脉慢血流(SCF)与阻塞性睡眠呼吸暂停综合征(OSAS)的相关性。方法：回顾性分析2017年1月~2019年12月于我院治疗的143例OSAS患者的临床资料，根据冠状动脉造影(CAG)结果将患者分为NSCF组(71例)及SCF组(72例)，分析比较两组患者的一般资料及相关实验室指标。结果：SCF组的男性患者比例、吸烟史、体重指数(BMI)、收缩压、舒张压、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、睡眠呼吸暂停低通气指数(AHI)、氧减指数(ODI)显著高于NSCF组(P < 0.05)；AHI与平均TIMI帧数、BMI、UA、舒张压、ODI呈显著正相关(P < 0.05)，与夜间最低脉搏血氧饱和度(LSPO2)呈显著负相关(P < 0.001)。Logistic回归分析显示AHI是OSAS合并SCF的独立危险因素(OR = 1.025, P < 0.05)。OSAS重度组(AHI > 30) SCF的患病率显著高于其余两组(P < 0.05)。结论：OSAS患者AHI与SCF密切相关，AHI升高是SCF的独立危险因素。
Object: To investigate the relationship between slow coronary flow (SCF) and obstructive sleep apnea syndrome (OSAS) in middle-aged patients. Methods: A total of 143 SCF patients in our department from January 2017 to December 2019 were selected and their clinical data were retrospectively analyzed. They were divided into NSCF group (n = 71) and SCF group (n = 72) based on the Coronary angiography (CAG). Data of demographics and laboratory measurements were compared and analyzed. Results: Compared to the patients in NSCF group, subjects of SCF group had markedly higher proportion of male patients, smoking history, body mass index (BMI), systolic blood pressure, diastolic blood pressure, triglyceride (TG), low density lipoprotein cholesterin (LDL-C), uric acid (UA), apnea and hypopnea index (AHI), Oxygen desaturation index (ODI) (P < 0.05). AHI was positively correlated with TIMI-TFC, BMI, UA, diastolic blood pressure, ODI (P < 0.05), and negatively correlated with the lowest pulse oxygen saturation (LSPO2) (P < 0.001). Logistic regression analysis showed that AHI was an independent risk factor of OSAS + SCF (OR = 1.025, P < 0.05), the prevalence of SCF in the severe OSAS group (AHI > 30) was significantly higher than those in the other two groups (P < 0.05). Conclusion: In OSAS patients AHI is inseparably associated with SCF. Increased AHI is an independent risk factor for SCF.