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UA、NLR对急性心肌梗死患者PCI术后预后的判断价值的研究
The Value of UA NLR in Predicting the Prognosis of Patients with Acute Myocardial Infarction after PCI

DOI: 10.12677/ACM.2020.109301, PP. 2009-2016

Keywords: 中性粒细胞与淋巴细胞的比率，尿酸，经皮冠状动脉介入治疗，MACE
Neutrophil to Lymphocyte Ratio, Uricacid, Percutaneous Coronary Intervention, MACE

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Abstract:

高中性粒细胞与淋巴细胞之比(neutrophil to lymphocyte ratio, NLR)和尿酸(uric acid, UA)的结合将更强地预测经皮冠状动脉介入治疗(percutaneous coronary intervention, PCI)后未来的心血管事件。在148例接受PCI的连续患者中测量了NLR和UA。主要终点是主要的不良心血管事件(major adverse cardiovascular Events, MACE)的发生率，包括心源性死亡、充血性心力衰竭、反复缺血性发作性心绞痛、再发心肌梗死、非计划再次血运重建、心源性再次住院、恶性心律失常。NLR和UA的中位数分别为4.89和344.71。在12个月的随访期间有45例MACE。数据分析显示，较高的NLR以及较高的UA组的MACE率明显高于较低的NLR组和/或较低的UA组。NLR和UA的组合可进一步增加MACE发生率的预测准确性。该值在急性心肌梗死(acute myocardial infarction, AMI)患者中特别有用。通过多变量Cox比例风险模型，高NLR和高UA的组合与MACE独立相关(P < 0.05)。高NLR和高UA的组合是PCI后MACE的独立预测指标，尤其是AMI患者。
We hypothesized that the combination of neutrophil to lymphocyte ratio (NLR) and uric acid (UA) is a better predictor of future cardiovascular events after percutaneous coronary intervention (PCI). NLR and UA were measured in 148 consecutive patients undergoing PCI. The primary endpoint was the incidence of major adverse cardiovascular events (MACE), including cardiac death, congestive heart failure, recurrent ischemic attack angina, recurrent myocardial infarction, unplanned revascularization, cardiogenic readmission, and malignant arrhythmia. The median of NLR and UA were 4.89 and 344.71, respectively. During the 12-month follow-up period, there were 45 cases of MACE. Data analysis showed that the MACE rate of higher NLR group and higher UA group was significantly higher than that of lower NLR group and/or lower UA group. The combination of NLR and UA can further improve the prediction accuracy of MACE incidence. This value is particularly useful in patients with acute myocardial infarction (AMI). By multivariate Cox proportional hazard model, the combination of high NLR and high UA was independently associated with MACE (P < 0.05). The combination of high NLR and high UA is an independent predictor of MACE after PCI, especially in patients with AMI.

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