A KRAS wild type mutational status confers a survival advantage in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is the fourth leading cause of cancer death in both men and women in the United States (1). In 2017, it is estimated that approximately 53,670 new cases will be diagnosed in the United States, and approximately 43,090 individuals will die from the disease (2). Over the last 10 years, the rates of pancreatic cancer have increased by approximately 0.5% each year (2). Despite encouraging advances in therapy, the 5-year survival rate continues to be dismal and is estimated at 8% for all stages of disease and less than 3% for distant disease