Primary hepatic neuroendocrine tumors: retrospective analysis of seven cases and literature review

Neuroendocrine tumors (NETs) are a group of highly heterogeneous diseases derived from the diffuse neuroendocrine system which are thought to be very rare (1). However, with further understanding of these diseases and improvement in the technologies available for their clinical diagnosis, larger numbers of NETs are being identified in developed countries. According to the American National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database, the incidence of gastroenteropancreatic NETs has increased in developed countries over the last 30 years (2,3). Brandolini et al. have shown that number of NETs continued to increase (4)