Discrepancies between ALK protein disruption and occurrence of ALK gene rearrangement in Polish NSCLC patients

Lung cancer (LC) is the most common cause of death among men and women considering cancer mortality in the word. The main causes of LC are smoking and exposure to radon. LC is predominantly detected in an advanced stage with poor prognosis. On molecular level LC is heterogeneous, however some molecular patterns of this disease could be observed. In non-small cell lung cancer (NSCLC), the presence of EGFR, ALK, ROS1, BRAF, MET and HER2 abnormalities might qualify patients to molecularly targeted treatment (in routine practice or in clinical trials)