Evaluation of gene panels for inherited cardiac disease—is less more?

In this issue of the Netherlands Heart Journal, van Lint et al. describe the yield of diagnostic next-generation sequencing (NGS) gene panels for cardiomyopathies and primary arrhythmia syndromes [1]. Historically, cardiogenetic testing was performed using Sanger sequencing, usually in a gene-by-gene fashion each requiring many months. In 2012, diagnostic NGS testing was introduced in the Netherlands, enabling rapid analysis of large gene panels simultaneously (e.？g. over 50 genes in 2–3 months), drastically improving cardiogenetic diagnostics