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-  2018 

Cyclin E1 and Rb modulation as common events at time of resistance to palbociclib in hormone receptor-positive breast cancer

DOI: 10.1038/s41523-018-0092-4

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Abstract:

Functional characterization of PDR and PDS BC cell lines. a Proliferation of PDS models treated with palbociclib 1?μM, palbociclib STC or 0.01% DMS0 (vehicle). b Proliferation of PDR models treated with palbociclib 1?μM or 0.01% DMS0 (vehicle). Growth rate was assessed at day 6 by methylene blue assay. Growth fold changes were computed as ratio, dividing growth rate of treated cells by their controls treated with drug vehicle. Mean value of growth fold change of three independent experiments ±standard error of the mean (SEM) was plotted (*P-values?<?0.05, two–way ANOVA with Sidak’s multiple comparisons test). c β-galactosidase activity of PDS and PDR models treated with palbociclib 1?μM or 0.01% DMS0 (vehicle). Positive and negative cells were counted in six randomly selected 20X fields and the percentage of positive cells was calculated. Mean percentage value of β-galactosidase positive cells of three independent experiments ±SEM was plotted (*P-values?<?0.05, by Student’s t test

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