Breast cancer chemoprevention pharmacogenomics: Deep sequencing and functional genomics of the ZNF423 and CTSO genes

The SERM-dependent, SNP-dependent “reversal” of estradiol induction of ZNF423 and BRCA1 expression in LCLs. a Estradiol (E2) and 4-hydroxytamoxifen (4OH-TAM) dose response curves for expression of ZNF423 (a) and BRCA1 (b) in LCLs with known genotypes for the ZNF423 intron 2 rs9940645 SNP. Values are mean？±？SEM for 8 determinations. (modified from Fig. 3, Ingle et al. Cancer Discovery 20136