Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer

A novel radiosensitizer screen nominates AR-inhibition as one of the most effective strategies in treating radioresistant BCC lines. Clonogenic survival assays were performed to determine the intrinsic RT sensitivity of 21 BCC lines (0–8？Gy RT) with significant heterogeneity in intrinsic radiosensitivity of the BC cell lines. IC50 values were determined for 130 clinically available compounds and correlation coefficients were calculated using IC50 values (for drug sensitivity) and surviving fraction after 2？Gy of radiation (SF-2Gy for radiation sensitivity). Bicalutamide was identified as one of the most effective drugs for treatment of radiation-resistant breast cancers (a) with a correlation coefficient of 0.46 (b