Restoration of GLP-1 secretion by Berberine is associated with protection of colon enterocytes from mitochondrial overheating in diet-induced obese mice

Inhibition of obesity and hyperlipidemia by BBR. a Body weight at 0, 4, and 8 weeks of treatment. b Average daily calorie intake per mouse. c Tissue weight of perirenal fat and epididymal fat pads after 8 weeks of treatment. d Serum lipid levels after 8 weeks of treatment. The BBR treatment was administrated for 8 weeks in DIO mice after 16 weeks on high-fat diet. Data are presented as the mean？±？SEM (n？=？6). *P？<？0.05 HFD versus NCD, #P？<？0.05 HFD？+？BBR versus HF