Emerging roles of TRIO and F-actin-binding protein in human diseases

Schematic Representation of TRIOBP Variants. a Structure of TRIO and F-actin-binding protein (TRIOBP) variants via alternative splicing. TRIOBP-1 and TRIOBP-4 do not share any genetic sequences. b Genetically deafness frequently was mutated in exons 6–9 of TRIOBP-4. c The first and second coiled-coil regions contain multimerization sites in TRIOBP-