Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes

Distribution of miR-1 targets in different tissues. By uploading the 398 target genes onto the David bioinformatics web site, we obtained the tissue distribution of 358 miR-1 targets. All of the miR-1 targets were classified into 3 parts: targets in foetal tissue, targets in mature tissue and targets associated with tumourigenesis. In each part, we analysed the percentage of miR-1 targets in each kind of tissue. For example, in mature tissue, 57% of the targets are distributed in brain tissue and 5% are located in the heart (red arrow