Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways

Antiproliferation effects of benzimidazoisoquinoline derivatives in human glioblastoma cells. Chemical structures of the synthetic benzimidazoisoquinoline derivatives were labeled by compounds 1A–I. IC50 values were also obtained after 48 h with treatment of compounds 1A–I at concentrations of 3.125–50 μmol/L in U87 and LN229 cells and represented as percentage of control as mean？±？SD of experiments performed at least three time