The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma

WWTR1 is overexpressed in GCA. a Expression of WWTR1 in GCA tumor tissue is significantly higher than in their adjacent normal gastric cardia tissue. The score distribution of IHC staining of WWTR1 in both GCA tumors (T) and their adjacent normal tissue (N) is shown in the box plots. The black dots at top are scores outside of the box plots. The mean scores and standard deviation are shown at bottom of the box plots. b IHC staining of WWTR1 in GCA tumor samples. Both WWTR1 negative (the top two panels) and positive (the bottom four panels) tumor samples are shown. Bar, 50 μm. c Two differentially stained WWTR1-positive GCA tumor samples with enlarged panels show no specific nuclear localization of WWTR1 in the tumor cells. Bar, 40 μ