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-  2018 

Oncolytic Viruses for Multiple Myeloma Therapy

DOI: 10.3390/cancers10060198

Keywords: multiple myeloma, oncolytic virotherapy, reovirus, measles virus, vesicular stomatitis virus, vaccinia virus, myxoma virus, adenovirus

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Abstract:

Although recent treatment advances have improved outcomes for patients with multiple myeloma (MM), the disease frequently becomes refractory to current therapies. MM thus remains incurable for most patients and new therapies are urgently needed. Oncolytic viruses are a promising new class of therapeutics that provide tumor-targeted therapy by specifically infecting and replicating within cancerous cells. Oncolytic therapy yields results from both direct killing of malignant cells and induction of an anti-tumor immune response. In this review, we will describe oncolytic viruses that are being tested for MM therapy with a focus on those agents that have advanced into clinical trials

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