全部 标题 作者 关键词 摘要
DOI: 10.3971/j.issn.1000-8578.2015.05.002
Keywords: A Meta-analysis,Effect of Rap2a on Invasion and Metastasis of Lung Cancer Cells and Its Related Mechanism,NSCLC的疫苗治疗研究进展,Immune Killing Effect of Silencing TIPE2 Expression on T Lymphocytes Against Lung Adenocarcinoma Cells LA795,Clinical Investigation on Qingfei Mixture Combined with Chemotherapy on Middle and Advanced Non-small Cell Lung Cancer,Effect of Vascular Endothelial Cadherin on Invasion and Metastasis of Non-small Cell Lung Cancer Cells and Related Mechanism,Advances of FGF/FGFR Signaling Pathway in Targeted Therapy for Squamous Cell Lung Cancer,Sulforaphane Suppressed Proliferation of Lung Cancer Stem Cells in vitro,Experiment of Different Administration Sequences of Apatinib and Paclitaxel on Lung Cancer,Cryptotanshinone Promotes Apoptosis of A549 Cells via Inhibiting Cap-dependent mRNA Translation
Full-Text Cite this paper Add to My Lib
摘要 目的 探讨肺癌中上皮间质转化通过Nrf2通路导致多药耐药的可能性。方法 TGF-β1诱导肺腺癌细胞发生上皮间质转化， Western blot法检测癌细胞发生上皮间质转化的标志分子和细胞核内Nrf2的表达变化；比色法测定GSH含量及GST活力的变化；MTT实验检测癌细胞发生上皮间质转化前后对顺铂耐药指数的变化。结果 TGF-β1使癌细胞发生了上皮间质转化：细胞失去极性，上皮标志分子E-cadherin表达下降，而间质标志分子Vimentin和Snail表达上升；细胞发生上皮间质转化后细胞核内Nrf2表达显著增加，GSH含量增高及GST活力增强，癌细胞对顺铂的耐药指数是原来的7.7倍。结论 肺癌上皮间质转化后可能通过Nrf2通路介导了癌细胞的多药耐药
Full-Text
Contact Us
service@oalib.com
QQ:3279437679
WhatsApp +8615387084133
