少突胶质细胞瘤中染色体1p/19q联合缺失与MGMT基因启动子甲基化的相关性
DOI: 10.3971/j.issn.1000-8578.2018.17.1543
Keywords: 胶质瘤少突胶质细胞瘤,1p/19q联合缺失,MGMT,甲基化,Detection of WNT7A Methylation in Peripheral Blood of NSCLC Patients and Its Diagnostic Value,Expression and DNA Methylation Status of Long Non-coding RNA ZNF667-AS1 in Esophageal Squamous Cell Carcinoma Tissues,Application of MGMT Promoter Methylation of Cerebrospinal Fluid in Diagnosis of Glioma,Clinical Significance of JAG1 Gene Methylation in Uygur Breast Cancer Patients,Research Progress on SPARC in Pathogenesis of Gastric Cancer,Expressions of SFRP1 Gene Methylation and SFRP1 Protein in Lung Adenocarcinoma and Related Clinical Significance,Methylation Status of MGMT Gene Promoter in Patients with Adenocarcinoma of Esophagogastric Junction and Its Relationship with Prognosis,Correlation of ChREBP mRNA Expression and Its CpG Island Methylation in Human Hepatocellular Carcinoma,Relationship of Methylation Status and mRNA Expression of PTEN, RASSF1A in Peripheral Blood with Thyroid Nodule Disease,Recent Advances of Correlation of Mismatch Repair System hMutS, hMutL Variation and Colorectal Cancer,Significance of Tumor Suppressor Gene TCF21 Promoter Methylation for Diagnosis and Prognosis of Renal Cell Carcinoma,Effect of Ubiquitin-like with PHD and Ring Finger Domain 1 on Invasion and Metastasis of Gastric Cancer and Related Mechanism,Epigenetic Mechanism of DNA Virus-mediated Carcinogenesis,Progress of Epigenetic Regulation of H3K27me3 and EZH2 in B-cell Non-Hodgkin's Lymphoma,Research Status and Development of Adherens Junction Associated Protein-1 in Gliomas
Abstract:
摘要 目的 研究少突胶质细胞瘤染色体1p/19q联合缺失与MGMT基因启动子甲基化的相关性。方法 选取少突胶质细胞瘤35例、间变型少突胶质细胞瘤32例标本作为实验组，星形细胞瘤20例及瘤旁正常脑组织标本20例作为对照组，荧光原位杂交方法检测染色体1p/19q联合缺失情况，巢式甲基化特异性PCR技术检测MGMT基因启动子甲基化情况。结果 少突胶质细胞瘤和间变型少突胶质细胞瘤1p/19q联合缺失率分别为85.71%、75.00%，均显著高于星形细胞瘤及正常脑组织（P<0.05）；少突胶质细胞瘤、间变型少突胶质细胞瘤、星形细胞瘤的MGMT基因启动子甲基化率均显著高于正常脑组织（P<0.05），但三者组间比较差异无统计学意义（P>0.05）；少突胶质细胞瘤1p/19q联合缺失与MGMT基因启动子甲基化呈正相关性，并且均与患者3年生存率相关（P<0.05）。结论 少突胶质细胞瘤中1p/19q联合缺失与MGMT基因启动子甲基化状态密切相关，联合检测有助于提高临床病理诊断的精确性，更好地评估预后
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