饲料中海南霉素研究应用现状
Review on Research and Application of Hainanmycin

DOI: 10.12677/HJAS.2019.910124, PP. 882-886

Keywords: 饲料添加剂，海南霉素，综述
Feed Additives, Hainanmycin, Review

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Abstract:

海南霉素是一种聚醚类抗生素，主要用来预防和治疗家禽球虫病和作为牛羊等家畜的饲用促生长剂使用，目前应用广泛但相关研究较少。本文对目前该药物的理化性质、作用机理、药效、毒性和检测方法进行了综述。结果表明：海南霉素具有一元酸多醚类结构，对革兰氏阳性菌作用效果好，通过干扰生物膜正常功能和跟球虫竞争与钠钾离子形成络合物起抗虫抗菌和促生长作用。近年来相关应用研究多为复方剂，相关检测方法较少且多为液相色谱–串联质谱方法。由此可知该抗生素的使用趋向于更安全和合理，相关残留分析检测方法仍很欠缺。
Hainanmycin is a new type of polyether antibiotics. It is mainly used for the prevention and treatment of poultry coccidiosis and applied as feed growth promoter for livestocks such as cattle and sheep. It is currently widely used while few research papers are published. Here we reviewed the physicochemical properties, mechanism of action, efficacy, toxicity and detection methods of hainanmycin. Hainanmycin has a monoacid polyether structure and good effect on Gram-positive bacteria. It plays an anti-insect, anti-bacterial and growth-promoting role by interfering with the normal function of biofilm, competing with coccidia and forming complex with sodium and potassium ions. In recent years, most of the related applications are focused on developing complex drugs, and most of the few reported analysis methods are liquid chromatography-tandem mass spectrometry (LC-MS). It can be concluded that the use of this antibiotic tends to be safer and more reasonable, and the relevant residual analysis methods are still lacking.

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