Background: The primary motor
cortex (M1) stimulation (MCS) is a useful tool for attenuation of
the peripheral neuropathic pain in patients with pharmacologically refractory
pain. Furthermore, that neurological procedure may also cause antinociception
in rodents with neuropathic pain. Cold allodynia is a frequent clinical finding
in patients with neuropathic pain, then, we evaluated if an adapted model of
neuropathy induced by chronic constriction injury (CCI) of the ischiadicusnervus (sciatic nerve) produces cold allodynia in an animal model of chronic pain. In
addition, we also investigated the effect of the electrical stimulation of the
M1 on chronic neuropathic pain condition in laboratory animals. Methods: Male Wistar rats were used. An adapted model of peripheral mononeuropathy
induced by CCI was carried out by placing a single loose ligature around the
right sciatic nerve. The acetone test was used to evaluate the cold allodynia
in CCI or Sham (without ligature) rats. The MCS (M1) was performed
at low-frequency (20μA, 100 Hz) during 15s by
deep brain stimulation (DBS-Thomas Recording device) 21 days after CCI or Sham
procedures. The cold allodynia was measured before and immediately after the
neurostimulation of M1 in the following time-window: 0, 15 and 30
min after MCS.Results:Cold
allodynia threshold increased in animals with chronic neuropathic pain
submitted to the acetone test 21 days after the CCI surgery. The M1-stimulation
by DBS procedure decreased the cold allodynia immediately and until 30 min
after M1-stimulation in rats with chronic neuropathic pain.Conclusion: The current
proposal
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