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-  2016 

LncRNA KCNQ1OT1在非小细胞肺癌组织中的表达及其临床意义

DOI: doi:10.7507/1671-6205.2016106

Keywords: LncRNA KCNQ1OT1, 非小细胞肺癌, 预后

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Abstract:

目的 探讨长链非编码RNA(LncRNA)KCNQ1OT1在非小细胞肺癌(NSCLC)肺组织中的表达及临床意义。 方法 收集2011年1月至2013年12月期间在四川省肿瘤医院行手术治疗的89例NSCLC患者的临床资料,采用实时荧光定量PCR法检测肺癌组织以及距离癌组织5 cm以上癌旁组织中LncRNA KCNQ1OT1的表达,结合临床资料分析其临床意义。 结果 与癌旁组织比较,LncRNA KCNQ1OT1在NSCLC组织中的表达水平明显增高( P<0.001)。单因素分析显示LncRNA KCNQ1OT1的表达与患者年龄、性别及病理类型无关( P>0.05),与肿瘤大小(χ 2=12.619, P<0.001)、淋巴结转移(χ 2=10.298, P=0.001)、TNM分期(χ 2=7.199, P=0.007)及吸烟史(χ 2=24.005, P<0.001)明显相关。生存分析提示LncRNA KCNQ1OT1高表达患者的总生存时间(20.0个月比35.0个月,χ 2=45.860, P<0.001)和中位无进展生存时间(12.0个月比24.0个月,χ 2=31.510, P<0.001)均显著低于低表达患者。Cox回归分析发现疾病分期和LncRNA KCNQ1OT1的表达可作为独立的预后不良的标志。 结论 LncRNA KCNQ1OT1在NSCLC组织标本中高表达,与患者的预后相关,可作为潜在的肺癌预后预测分子标志物

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