纳米羟基磷灰石/聚酰胺6医用复合材料的制备及性能表征
Preparation and properties characterization of nano hydroxyapatite/polyamide 6 biomedical composites

为防止纳米羟基磷灰石(nano HAP)粉末的团聚, 采用溶剂沉淀法制备了nano HAP/聚酰胺6(PA6)复合粉末, 并对粉末进行热压成型制得nano HAP/PA6复合材料.然后, 通过FTIR、XRD和SEM对nano HAP/PA6复合材料的成分、结构和形貌进行了表征, 并对复合材料的热稳定性、力学性能和细胞相容性进行了检测.结果表明:所制备的nano HAP/PA6复合材料结晶体大小均匀, 且PA6只存在α型结晶;由于nano HAP与PA6界面上形成新的氢键和COO—Ca, 复合材料具有良好的综合性能;在低于350 ℃时, nano HAP/PA6复合材料不会发生裂解, 力学性能与人骨匹配, 50wt% nano HAP/PA6复合材料的弯曲强度、压缩强度和弹性模量分别为146.87 MPa、98.44 MPa和5.44 GPa. MG-63骨瘤细胞在nano HAP/PA6复合材料表面粘附和生长状况良好, 说明nano HAP/PA6复合材料具有良好的细胞相容性.所得结论表明nano HAP/PA6复合材料在骨修复方面具有应用价值. In order to prevent the conglomerating of nano hydroxyapatite (nano HAP) powders, the nano HAP/polyamide 6 (PA6) composite powders were prepared by solvent precipitation method, and nano HAP/PA6 composites were obtained through hot-press forming of the powders. Then, the constituent, structure and morphology of nano HAP/PA6 composites were investigated using FTIR, XRD and SEM, and thermal stability, mechanical properties and cellular compatibility of composites were measured as well. The results show that the crystalline size of prepared nano HAP/PA6 composites is uniform, and PA6 only has the crystal of α form. For new hydrogen bonds and COO—Ca forming on the interface of nano HAP and PA6, the composites have good synthetic performances. Nano HAP/PA6 composite does not split within 350 ℃, and the mechanical properties are close to human skeleton. The bending strength, compressive strength and elastic modulus of 50wt% nano HAP/PA6 composite are 146.87 MPa, 98.44 MPa and 5.44 GPa, respectively. The situations of MG-63 bone tumor cells attaching and growth on the surfaces of nano HAP/PA6 composites are good, which indicates the nano HAP/PA6 composites have good cellular compatibility. The conclusions obtainted show that nano HAP/PA6 composites have application values in bone repair aspect. 国家自然科学基金(51274247);中南大学研究生自主探索创新项目(2014zzts177)