线粒体蛋白转运系统的序列相似性分析
Sequence similarity analysis of the mitochondrial protein import machinery

通过在27个不同进化层次物种的基因组和蛋白组中搜索酵母线粒体蛋白转运系统亚基的同源序列, 并进一步分析了同源亚基序列相似性与其所在线粒体位置的关系. 结果表明, 位于线粒体相同位置的模块有类似的序列相似性曲线, 相似性曲线在模块内部一般有波峰和波谷. 从线粒体外膜到基质, 序列相似性整体升高. 线粒体蛋白转运系统亚基与一些功能不相关的蛋白也表现出序列相似关系, 且这些亚基多集中在线粒体的内膜和外膜.
The homology sequence of Saccharomyces cerevisiae mitochondrial protein import machinery subunits in the genomes and proteomes of 27 species in different evolution levels were searched, and further analysis the relationship between sequence similarity of the subunits and their mitochondria location. The result reveals that modules in the same position of mitochondria show a similar sequence similarity curve. In the same module, sequence similarity curve always have its own peaks and troughs. On the whole, the sequence similarity rise from the outer membrane to matrix of the mitochondria. Furthermore, mitochondrial protein import machinery subunits also show sequence similarity with some function not associated proteins, and these subunits generally concentration on the outer and inner membrane of the mitochondria