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- 2016
纳米羟基磷灰石表面阿伦膦酸钠和I型胶原蛋白复合膜的制备
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Abstract:
摘要 目的:在纳米羟基磷灰石(nHA)涂层表面制备稳定可重复的阿伦膦酸钠(ALN)和I型胶原蛋白(COL I)复合膜。方法:在纯钛(PT)表面电化学沉积nHA涂层,以3-氨丙基三乙氧基硅烷(APTES)、1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)为偶联剂,在涂层表面结合ALN和COL I,制备nHA/ALN/COL I和nHA/COL I/ALN复合膜。通过扫描电子显微镜(SEM),X射线能谱分析仪(EDS)和X射线衍射仪(XRD)表征nHA涂层,通过X射线光电子能谱仪(XPS)和傅里叶红外光谱仪(FTIR)表征复合膜。结果:ALN和COL I可通过偶联剂结合于nHA涂层,改变其结合次序,可分别形成nHA/ALN/COL I和nHA/COL I/ALN复合膜。结论:通过化学结合法形成的nHA/ALN/COL I和nHA/COL I/ALN复合膜具有不同的ALN缓释潜力
| [1] | Hu R, Lin CJ, Shi HY. A novel ordered nano hydroxyapatite coating electrochemically deposited on titanium substrate [J]. J Biomed Mater Res A, 2007, 80(3)∶687-692 |
| [2] | Mostafa NY. Characterization, thermal stability and sintering of hydroxyapatite powders prepared by different routes [J]. Mater Chem Phys, 2005, 94(2-3)∶333-341 |
| [3] | Bose S, Tarafder S. Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review [J]. Acta Biomater, 2012, 8(4)∶1401-1421 |
| [4] | Boanini E, Torricelli P, Gazzano M, et al. Alendronate-hydroxyapatite nanocomposites and their interaction with osteoclasts and osteoblast-like cells [J]. Biomaterials, 2008, 29(7)∶790-796 |
| [5] | Al-Sanabani J, Madfa AA, Al-Sanabani FA. Application of Calcium Phosphate Materials in Dentistry [J]. Int J Biomater, 2013, 2013(1)∶1-12 |
| [6] | Bakhsheshi-Rad HR, Hamzah E, Daroonparvar M, et al. In-vitro degradation behavior of Mg alloy coated by fluorine doped hydroxyapatite and calcium deficient hydroxyapatite [J]. Trans Nonferrous Met So, 2014, 24(8)∶2516-2528 |
| [7] | Russo L, Taraballi F, Lupo C, et al. Carbonate hydroxyapatite functionalization: a comparative study towards (bio)molecules fixation [J]. Interface Focus, 2014, 4(1)∶1-8 |
| [8] | Mendona G, Mendona DB, Arago FJ, et al. Advancing dental implant surface technology-from micron- to nanotopography [J]. Biomaterials, 2008, 29(28)∶3822-3835 |
| [9] | Niu S, Cao X, Zhang Y, et al. The inhibitory effect of Alendronate-hydroxyapatite composite coating on wear debris-induced peri-implant high bone turnover [J]. J Surg Res, 2012, 179(1)∶e107-e115 |
| [10] | Albrektsson T, Wennerberg A. Oral implant surfaces: Part 1--review focusing on topographic and chemical properties of different surfaces and in vivo responses to them [J]. Int J Prosthodont, 2004, 17(5)∶536-543 |
| [11] | Cattalini JP, Boccaccini AR, Lucangioli S, et al. Bisphosphonate-based strategies for bone tissue engineering and orthopedic implants [J]. Tarafder S Tissue Eng Part B Rev, 2012, 18(5)∶323-340 |
| [12] | Wen C, Guan S, Peng L, et al. Characterization and degradation behavior of AZ31 alloy surface modified by bone-like hydroxyapatite for implant applications [J]. Appl Surf Sci, 2009, 255(13-14)∶6433-6438 |
| [13] | Stoch A, Broek A, Biaewicz S, et al. FTIR study of electrochemically deposited hydroxyapatite coatings on carbon materials [J]. J Mole Struct, 2003, 651-653(1)∶389-396 |
| [14] | Ribeiro N, Sousa SR, Monteiro FJ. Influence of crystallite size of nanophased hydroxyapatite on fibronectin and osteonectin adsorption and on MC3T3-E1 osteoblast adhesion and morphology [J]. J Colloid Interface Sci, 2010, 351(2)∶398-406 |
| [15] | Rodrigues SC, Salgado CL, Sahu A, et al. Preparation and characterization of collagen-nanohydroxyapatite biocomposite scaffolds by cryogelation method for bone tissue engineering applications [J]. J Biomed Mater Res A, 2013, 101(4)∶1080-1094 |
| [16] | Chen JH, Luo Y, Hong LQ, et al. Synthesis, characterization and osteoconductivity properties of bone fillers based on alendronate-loaded poly(e-caprolactone)/hydroxyapatite microspheres [J]. J Mater Sci Mater Med, 2011, 22(3)∶547-555 |
| [17] | Cattalini JP, Boccaccini AR, Lucangioli S, et al. Bisphosphonate-based strategies for bone tissue engineering and orthopedic implants [J]. Tarafder S Tissue Eng Part B Rev, 2012, 18(5)∶323-340 |
| [18] | Patino MG, Neiders ME, Andreana S, et al. Collagen as an implantable material in medicine and dentistry [J]. J Oral Implantol, 2002, 28(5)∶220-225 |
| [19] | Sheu MT, Liu CH, Sokoloski TD. Prolongation of drug release by covalent bonding of drugs to serum albumin microbeads [J]. Drug Des Deliv, 1991, 7(4)∶251-257 |
| [20] | Allen MR, Gineyts E, Leeming DJ, et al. Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra [J]. Osteoporos Int, 2008, 19(3)∶329-337 |
| [21] | 计艳,胡勤刚,童昕,等.新型种植体涂层材料rhBMP-2/PDLLA诱导成骨作用的观察[J].口腔医学研究,2009,25(1)∶4-7 |
