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- 2018
Adrb2激动剂、拮抗剂对大鼠牙移动中牙槽骨微结构改建的影响研究
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Abstract:
摘要 目的:讨论β-2肾上腺素受体(β-2 adrenergic receptor,Adrb2)激动剂、拮抗剂对大鼠正畸牙移动牙槽骨微结构改建、破骨细胞生成的影响。方法:64只雌性SD大鼠随机分成异丙肾上腺素组、普萘洛尔组、阴性对照组及生理盐水(stroke-physiological saline solution,SPSS)组。建立大鼠正畸牙移动模型,按体重分别于腹腔注射相应药物,0 d、7 d、14 d、21 d处死大鼠,游标卡尺测量第一磨牙移动距离, TRAP染色观察破骨细胞数量,Micro-CT评价牙槽骨微结构变化。结果:牙移动距离、破骨细胞计数均表现为:异丙肾上腺素组>生理盐水组>普萘洛尔组>阴性对照组,差异有统计学意义(P<0.05),Micro-CT扫描结果发现异丙肾上腺素能够降低骨体积分数(BV/TV)与骨小梁密度(MTPD),升高骨小梁分离度(Tb.sp),而普萘洛尔则刚好相反。结论:肾上腺素能够促进压力侧牙槽骨的吸收、破骨细胞的生成,使牙槽骨变得疏松而利于正畸牙的移动;普萘洛尔抑制破骨细胞的生成、增加牙槽骨骨密度而减缓牙齿移动
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