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-  2016 

番茄红素对大鼠心肌梗死后心功能及心肌细胞凋亡的影响 Effects of Lycopene on Cardiac Function and Myocardial Apoptosis in Myocardial Infarction Rats

Keywords: 心肌梗死,心室重构,心肌细胞凋亡,心功能,番茄红素

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Abstract:

目的:观察番茄红素对大鼠心肌梗死后心功能及心肌细胞凋亡的影响。方法:通过结扎大鼠冠状动脉前降支制备心肌梗死模型,分别给予番茄红素及生理盐水灌胃。28d后行心脏超声及血流动力学检测心功能,Tunel染色检测心肌细胞凋亡,Western blot法检测梗死周边Caspase-3蛋白表达。结果:心梗后,LVEF、FS、LVESP、-dP/dt、+dP/dt显著降低(P<0.05),LVEDD、LVESD、LVEDP显著升高(P<0.05),心肌细胞凋亡指数显著上升(P<0.05),梗死周边区Caspase-3蛋白表达水平显著上调。与心梗对照组相比,番茄红素治疗组LVEF、FS、LVESP、-dP/dt、+dP/dt显著升高(P<0.05),LVEDD、LVESD、LVEDP显著降低(P<0.05),心肌细胞凋亡指数显著下降(P<0.05),梗死周边区Caspase-3蛋白表达水平下调。结论:番茄红素可能通过抑制心梗后心肌细胞凋亡逆转心室重构,从而改善心功能

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