维生素D水平对产后小鼠情绪及运动能力的影响

目的 探讨维生素D水平对小鼠产后情绪、运动能力等行为的影响。方法 产后小鼠给予不同剂量水平的维生素D,包括正常摄取剂量(1000IU/kg)、缺乏摄取剂量(0IU/kg)和过量摄取剂量(10000IU/kg),利用旷场实验、黑白箱穿梭实验、悬尾实验、强迫游泳和转棒实验等行为范式连续10周跟踪检测小鼠的行为表型。结果 旷场实验和转棒实验表明维生素D对小鼠的自发活动和运动协调能力基本没有影响；黑白箱实验中小鼠在白箱停留时间和黑白箱穿梭次数均没有差异,因此维生素D对小鼠产后焦虑情绪没有影响；悬尾试验和强迫游泳实验结果提示三组小鼠的不动状态从整体变化趋势来看基本接近。结论 维生素D水平长期摄取对小鼠产后焦虑、抑郁情绪和产后运动能力没有持续性影响。
Objective To investigate the effects of vitamin D on postpartum mood and athletic performance in mice. Methods Vitamin D was given to postpartum mice for 14 weeks, with a normal dose (n=27,1000IU/kg), deficient dose (n=25,0IU/kg) or overdose (n=22,0000IU/kg). The maternal depressive-like behaviors was examined by using tail suspension test (TST), forced swim test (FST), dark-light box (DLB), open field and rotarod for 10 weeks. Results Vitamin D had little effect on the athletic activity with open field and rotarod tests. Dark-light box revealed that there was no effect of vitamin D on the anxiety. In addition, tail suspension and forced swim tests indicated that vitamin D had no effect on postpartum depression. Conclusion Vitamin D shows no persistent effect on athletic activity and postpartum mood in mice