HE4与慢性心力衰竭患者心功能的相关性

目的探讨慢性心力衰竭患者HE4水平与心功能的关系。方法选取因慢性心力衰竭住院的200例患者为研究对象，平均年龄（71.81±12.49）岁。将心功能Ⅰ-Ⅱ级定义为心功能不全低危组，将心功能Ⅲ-Ⅳ级定义为心功能不全高危组。多因素Logistic回归分析评估导致慢性心力衰竭发生的危险因素。结果BMI、HDL-C等指标心功能不全高危组与心功能不全低危组组间差异无统计学意义（P≥0.05）；而LDL-C、CRP、HE4、UA等指标两组间差异有统计学意义（P＜0.05）。当调节变量包括年龄、性别、HE4以及NT-proBNP时，HE4和NT-proBNP是与慢性心力衰竭患者心功能密切相关的危险因素。而当调节变量包括年龄、性别、HE4、NT-proBNP、吸烟、饮酒、HDL-C、LDL-C以及UA时，结果提示性别、HE4和NT-proBNP是与慢性心力衰竭患者心功能密切相关的危险因素。结论性别、HE4和NT-proBNP是与慢性心力衰竭患者心功能密切相关的危险因素，慢性心力衰竭患者HE4水平与心功能的分级存在相关关系。
ObjectiveTo investigate the relationship between human epididymis protein 4（HE4）level and cardiac function in chronic heart failure patients. MethodsTwo hundred patients aged 71.81±12.49 years with chronic heart failure admitted in hospital were enrolled in the study. Patient were divided into low risk heart failure group (grade Ⅰ-Ⅱ) and high risk heart failure group (grade Ⅲ-Ⅳ). The risk factors of chronic heart failure were analyzed with Logistic regression. ResultsThere were no significant differences in BMI and HDL-c between two groups（P≥0.05）, while there were significant differences in LDL-C，CRP，HE4 and UA between two groups（P＜0.05）. HE4 and NT-proBNP were independent risk factors for predicting cardiac insufficiency. The gender, HE4 level and NT-proBNP were independent risk factors of cardiac dysfunction when age, sex, HE4, NT-proBNP, smoking, drinking, HDL-C, LDL-C and UA were adjusted. ConclusionGender, HE4 and NT-proBNP are independent risk factors of cardiac insufficiency, and HE4 levels are associated with the classification of cardiac function in chronic heart failure patients