综合干预对急性冠脉综合征伴发焦虑抑郁患者生活质量的影响

目的 探讨综合干预措施对急性冠脉综合征(acute coronary syndrome, ACS)伴发焦虑抑郁患者生活质量(quality of life, QOL)的影响。方法 对218例伴发不同程度焦虑抑郁情绪的ACS患者随机分为常规治疗组(n=109)和干预组(n=109)。对照组扩血管、抗凝、调节血脂、控制心衰、改善心肌重构,干预组在此基础上给予综合性非药物干预包括疾病相关健康讲座、生活方式和运动指导、放松训练、针对性的认知行为治疗。运用一般健康状况评估量表SF-36对所有入组患者定期进行QOL的随访。结果平均随访时间为(10.32±2.11)个月。在SF-36的8个维度中,干预组的生理功能(physiological function, PF)、生理职能(physiological requirement, PR)、躯体疼痛(body pain, BP)、活力(vitality, VT)、精神健康(mental health, MH)评分均高于常规治疗组(P＜0.05)。结论 对于伴发焦虑抑郁情绪的ACS患者,在常规治疗基础上给予针对性综合干预更有利于改善患者的QOL。
Objective To assess the quality of life(QOL)of acute coronary syndrome(ACS)patients complicated with anxiety and depression receiving comprehensive intervention. MethodsTwo hundred and eighteen ACS patients with anxiety and/or depression symptoms were randomly assigned into intervention group (n=109) and control group (109). Both groups received conventional therapy; additional comprehensive intervention, including health education, exercise, psychological relaxation, was given to intervention group. Hospital anxiety depression scale (HADS) and SF-36 scores were assessed before and after intervention. ResultsAfter(10.32±2.11)months of follow-up,among 8 domains of SF-36 the scores in physical function(PF), role-physical(RP), bodily pain(BP), vitality(VT) and mental health(MH)were higher than those in control group(P＜0.05). ConclusionComprehensive intervention can alleviate anxiety and/or depression symptoms of ACS patients and improve their quality of life