儿童Wilms瘤分子分型标志物的研究进展

Wilms瘤是儿童最常见的肾脏恶性肿瘤。随着各项医疗手段的发展，Wilms瘤患儿生存率有了很大提高。研究表明，Wilms瘤因不同的组织学分型具有不同的预后。加深对肿瘤分子层面的认识能够使我们更好地了解肿瘤的生物学特性并对不同肿瘤进行区分，以帮助指导儿童Wilms瘤的治疗和预后判断。本文就儿童Wilms瘤在分子分型标志物研究方面的进展作一综述。
Wilms tumor (nephroblastoma) is the most common malignant renal tumors of childhood. With the development of various medical skills, the survival rate has been greatly improved for Wilms tumor children. Researches have shown that patients with Wilms tumor have different outcomes due to diverse histological classification. Deepening the understanding of tumor molecular typing may help to understand the biological characteristics of tumor better and distinguish different tumors, contributing to treatment and prognosis prediction of children with Wilms tumor. In this review, we summarized the progress of molecular typing markers in pediatric Wilms tumor