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- 2018
Temozolomideresistanceinhighgradegliomas#br#
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Abstract:
High grade gliomas are always the research focus in the field of neurosurgery due to their poor prognosis despite the current standard therapeutic？regimen？of？surgical？resection？followed？by？radiation？therapy？and？chemotherapy.？Alkylating？agent？temozolomide？has？been？established？as？the？ standard？chemotherapy？while？its？resistance？inevitable？during？treatment.？This？phenomenon？seriously？influences？the？prognosis？of？patients？suffering？from？ high grade gliomas. This review aims to elucidate temozolomide chemoresistance mechanisms through three chapters including O6-methylguanine-DNA methyltransferase？(MGMT)？methylation,？mismatch？repair？mutation？and？epigenetic？regulation？consisting？of？p21,？chromatin？and？histone,？Y-box？binding？ protein-1 and microRNAs.
：High grade gliomas are always the research focus in the field of neurosurgery due to their poor prognosis despite the current standard therapeutic？regimen？of？surgical？resection？followed？by？radiation？therapy？and？chemotherapy.？Alkylating？agent？temozolomide？has？been？established？as？the？ standard？chemotherapy？while？its？resistance？inevitable？during？treatment.？This？phenomenon？seriously？influences？the？prognosis？of？patients？suffering？from？ high grade gliomas. This review aims to elucidate temozolomide chemoresistance mechanisms through three chapters including O6-methylguanine-DNA methyltransferase？(MGMT)？methylation,？mismatch？repair？mutation？and？epigenetic？regulation？consisting？of？p21,？chromatin？and？histone,？Y-box？binding？ protein-1 and microRNAs
