Objectives: To study the therapeutic effects of “Lingqi Huangban Granule” (LQHB) combined with
intravitreal ranibizumab injection (IVR) for choroidal neovascularisation (CNV)
in pathologic myopia (PM).Methods:
This was a prospective, comparative, interventional study. Eighty eyes of
eighty consecutive patients with myopic CNV were randomized into control group
(IVR, 40 eyes) and integrative therapy group (IVR + LQHB, 40 eyes), each with a
follow-up period of 12 months. IVR was given with an “on demand” regimen (Pro re nata, PRN). Final best corrected visual acuity (BCVA)
and its change from baseline were the main outcome measures. Changes in optical
coherence tomography (OCT) and central retinal thickness (CRT) were the
secondary outcome measures.Results:
BCVA of patients in the integrative group improved significantly (from 47.10±13.51 letters to 90.72±12.98 letter, P<0.05), more than in the control group (from 42.90±13.18 letters to 69.18±13.21
letters, P<0.05) since the third month after the initial treatment to the end of the
follow-up. Mean OCT CRT reduced from 364.75
References
[1]
Ohno-Matsui, K., Lai, T.Y., Lai, C.C. and Cheung, C.M. (2016) Updates of Pathologic Myopia. Progress in Retinal and Eye Research, 52, 156-187.
http://dx.doi.org/10.1016/j.preteyeres.2015.12.001
[2]
Verkicharla, P.K., Ohno-Matsui, K. and Saw, S.M. (2015) Current and Predicted Demographics of High Myopia and an Update of Its Associated Pathological Changes. Ophthalmic and Physiological Optics, 35, 465-475. http://dx.doi.org/10.1111/opo.12238
[3]
Teo, K.Y., Ng, W.Y., Lee, S.Y. and Cheung, C.M. (2016) Management of Myopic Choroidal Neovascularization: Focus on Anti-VEGF Therapy. Drugs, 76, 1119-1133.
http://dx.doi.org/10.1007/s40265-016-0605-0
[4]
Munk, M.R., Rückert, R., Zinkernagel, M., Ebneter, A. and Wolf, S. (2016) The Role of Anti-VEGF Agents in Myopic Choroidal Neovascularization: Current Standards and Future Outlook. Expert Opinion on Biological Therapy, 16, 477-487.
http://dx.doi.org/10.1517/14712598.2016.1132696
[5]
Zhang, Y., Han, Q., Ru, Y., Bo, Q. and Wei, R.H. (2015) Anti-VEGF Treatment for Myopic Choroid Neovascularization: From Molecular Characterization to Update on Clinical Application. Drug Design, Development and Therapy, 9, 3413-3421.
http://dx.doi.org/10.2147/DDDT.S87920
[6]
Morgan, I.G., He, M. and Rose, K.A. (2016) Epidemic of Pathologic Myopia: What Can Laboratory Studies and Epidemiology Tell Us? Retina.
http://dx.doi.org/10.1097/IAE.0000000000001272
[7]
Pakzad-Vaezi, K., Mehta, H., Mammo, Z. and Tufail, A. (2016) Vascular Endothelial Growth Factor Inhibitor Use and Treatment Approach for Choroidal Neovascularization Secondary to Pathologic Myopia. Expert Opinion on Biological Therapy, 16, 873-881.
http://dx.doi.org/10.1517/14712598.2016.1167868
[8]
Ji, L., Lv, W., Xiao, Y., Xu, Z., Zhang, X. and Zhang, W. (2015) Therapeutic Effect of Intravitreal Injections of Ranibizumab for the Treatment of Macular Choroidal Neovascularization Caused by Pathological Myopia. Experimental and Therapeutic Medicine, 10, 1121-1126.
[9]
Ladaique, M., Dirani, A. and Ambresin, A. (2015) Long-Term Follow-Up of Choroidal Neovascularization in Pathological Myopia Treated with Intravitrealranibizumab. Klin Monbl Augenheilkd, 232, 542-547. http://dx.doi.org/10.1055/s-0035-1545817
[10]
Lu, B.W. and Wu, X.W. (2015) Clinical Study of Sulfotanshinone Sodium Injection in Treating Non-Ischemic Retinal Vein Occlusion. Chinese Medicine, 6, 83-89.
http://dx.doi.org/10.4236/cm.2015.62009
[11]
Lu, B.W. and Wu, X.W. (2015) Retinal Functional Changes Measured by Microperimetry after Intravitreal Ranibizumab Injection and Sulfotanshinone Sodium Injection for Macular Edema Secondary to Retinal Vein Occlusion. Chinese Medicine, 6, 181-186.
http://dx.doi.org/10.4236/cm.2015.63020
[12]
Gong, Y.Y., Song, Y., Xie, Z.G. and Wu, X.W. (2008) Protective Effect of Huangban Granule against Light-Induced Retinal Damage in Rats. Zhong Xi Yi Jie He Xue Bao, 6, 1159-1163. http://dx.doi.org/10.3736/jcim20081110
[13]
Li, C.H., Qiu, Q.H., Wu, X.W., Gong, Y.Y., Xie, Z.G., Song, Y. and Gu, Q. (2012) Chinese Herbal Medicine Lingqi Huangban Granule Protects Retinal Pigment Epithelial Cells Against Oxidative Stress-Induced Injury in Vitro. Zhong Xi Yi Jie He Xue Bao, 10, 85-90.
http://dx.doi.org/10.3736/jcim20120113
